Cargando…

Severe Corneal Edema Increases ECL From Grafts After DSAEK—Corneal Edema and ECL After DSAEK

To determine the relationship between the preoperative degree of corneal edema in the recipient and the endothelial cell density in grafts after Descemet stripping automated endothelial keratoplasty (DSAEK). METHODS: This retrospective case series enrolled 111 eyes of 107 patients who underwent DSAE...

Descripción completa

Detalles Bibliográficos
Autores principales: Gu, Shaofeng, Peng, Rongmei, Xiao, Gege, Hong, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Eye & Contact Lens: Science & Clinical Practice 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9119398/
https://www.ncbi.nlm.nih.gov/pubmed/34739409
http://dx.doi.org/10.1097/ICL.0000000000000857
_version_ 1784710693471125504
author Gu, Shaofeng
Peng, Rongmei
Xiao, Gege
Hong, Jing
author_facet Gu, Shaofeng
Peng, Rongmei
Xiao, Gege
Hong, Jing
author_sort Gu, Shaofeng
collection PubMed
description To determine the relationship between the preoperative degree of corneal edema in the recipient and the endothelial cell density in grafts after Descemet stripping automated endothelial keratoplasty (DSAEK). METHODS: This retrospective case series enrolled 111 eyes of 107 patients who underwent DSAEK. The preoperative and postoperative central corneal thickness (CCT) was measured by anterior-segment optical coherence tomography. Eyes were divided into three groups according to the preoperative recipient CCT: group A (mild edema): 550 μm<CCT≤750 μm, n=38; group B (moderate edema): 750 μm<CCT≤900 μm, n=51; and group C (severe edema): 900 μm<CCT≤1,500 μm, n=22. The endothelial cell loss (ECL) was calculated by in vivo confocal microscopy and compared at 1, 6, 12, and 24 months after surgery. RESULTS: The recipient CCT (all groups combined) was 805.99±132.70 μm preoperatively and decreased to 656.31±105.02 μm at 1 month, decreased to 626.08±81.40 μm at 6 months, and remained stable between 12 (P=0.144) and 24 months (P=0.485) postoperatively. The mean ECL was 27.34±15.43%, 33.56±17.13%, 39.18±16.71%, and 45.87±14.27% at 1, 6, 12, and 24 months, respectively. The percentage of ECL in group C was higher than that in the other 2 groups through the 24-month follow-up. The difference in ECL between groups A and C was significant at 24 months (group A: 42.45±14.47%; group C: 52.49±10.65%; P=0.019). CONCLUSIONS: The degree of corneal edema in the recipient was associated with implant ECL. Compared with mild and moderate corneal edema, the severe corneal edema may cause greater ECL after DSAEK.
format Online
Article
Text
id pubmed-9119398
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Eye & Contact Lens: Science & Clinical Practice
record_format MEDLINE/PubMed
spelling pubmed-91193982022-05-25 Severe Corneal Edema Increases ECL From Grafts After DSAEK—Corneal Edema and ECL After DSAEK Gu, Shaofeng Peng, Rongmei Xiao, Gege Hong, Jing Eye Contact Lens Article To determine the relationship between the preoperative degree of corneal edema in the recipient and the endothelial cell density in grafts after Descemet stripping automated endothelial keratoplasty (DSAEK). METHODS: This retrospective case series enrolled 111 eyes of 107 patients who underwent DSAEK. The preoperative and postoperative central corneal thickness (CCT) was measured by anterior-segment optical coherence tomography. Eyes were divided into three groups according to the preoperative recipient CCT: group A (mild edema): 550 μm<CCT≤750 μm, n=38; group B (moderate edema): 750 μm<CCT≤900 μm, n=51; and group C (severe edema): 900 μm<CCT≤1,500 μm, n=22. The endothelial cell loss (ECL) was calculated by in vivo confocal microscopy and compared at 1, 6, 12, and 24 months after surgery. RESULTS: The recipient CCT (all groups combined) was 805.99±132.70 μm preoperatively and decreased to 656.31±105.02 μm at 1 month, decreased to 626.08±81.40 μm at 6 months, and remained stable between 12 (P=0.144) and 24 months (P=0.485) postoperatively. The mean ECL was 27.34±15.43%, 33.56±17.13%, 39.18±16.71%, and 45.87±14.27% at 1, 6, 12, and 24 months, respectively. The percentage of ECL in group C was higher than that in the other 2 groups through the 24-month follow-up. The difference in ECL between groups A and C was significant at 24 months (group A: 42.45±14.47%; group C: 52.49±10.65%; P=0.019). CONCLUSIONS: The degree of corneal edema in the recipient was associated with implant ECL. Compared with mild and moderate corneal edema, the severe corneal edema may cause greater ECL after DSAEK. Eye & Contact Lens: Science & Clinical Practice 2022-06 2021-11-04 /pmc/articles/PMC9119398/ /pubmed/34739409 http://dx.doi.org/10.1097/ICL.0000000000000857 Text en Copyright © 2021 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the Contact Lens Association of Opthalmologists. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
spellingShingle Article
Gu, Shaofeng
Peng, Rongmei
Xiao, Gege
Hong, Jing
Severe Corneal Edema Increases ECL From Grafts After DSAEK—Corneal Edema and ECL After DSAEK
title Severe Corneal Edema Increases ECL From Grafts After DSAEK—Corneal Edema and ECL After DSAEK
title_full Severe Corneal Edema Increases ECL From Grafts After DSAEK—Corneal Edema and ECL After DSAEK
title_fullStr Severe Corneal Edema Increases ECL From Grafts After DSAEK—Corneal Edema and ECL After DSAEK
title_full_unstemmed Severe Corneal Edema Increases ECL From Grafts After DSAEK—Corneal Edema and ECL After DSAEK
title_short Severe Corneal Edema Increases ECL From Grafts After DSAEK—Corneal Edema and ECL After DSAEK
title_sort severe corneal edema increases ecl from grafts after dsaek—corneal edema and ecl after dsaek
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9119398/
https://www.ncbi.nlm.nih.gov/pubmed/34739409
http://dx.doi.org/10.1097/ICL.0000000000000857
work_keys_str_mv AT gushaofeng severecornealedemaincreaseseclfromgraftsafterdsaekcornealedemaandeclafterdsaek
AT pengrongmei severecornealedemaincreaseseclfromgraftsafterdsaekcornealedemaandeclafterdsaek
AT xiaogege severecornealedemaincreaseseclfromgraftsafterdsaekcornealedemaandeclafterdsaek
AT hongjing severecornealedemaincreaseseclfromgraftsafterdsaekcornealedemaandeclafterdsaek