Clofoctol inhibits SARS-CoV-2 replication and reduces lung pathology in mice

Drug repurposing has the advantage of shortening regulatory preclinical development steps. Here, we screened a library of drug compounds, already registered in one or several geographical areas, to identify those exhibiting antiviral activity against SARS-CoV-2 with relevant potency. Of the 1,942 co...

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Detalles Bibliográficos
Autores principales: Belouzard, Sandrine, Machelart, Arnaud, Sencio, Valentin, Vausselin, Thibaut, Hoffmann, Eik, Deboosere, Nathalie, Rouillé, Yves, Desmarets, Lowiese, Séron, Karin, Danneels, Adeline, Robil, Cyril, Belloy, Loic, Moreau, Camille, Piveteau, Catherine, Biela, Alexandre, Vandeputte, Alexandre, Heumel, Séverine, Deruyter, Lucie, Dumont, Julie, Leroux, Florence, Engelmann, Ilka, Alidjinou, Enagnon Kazali, Hober, Didier, Brodin, Priscille, Beghyn, Terence, Trottein, François, Deprez, Benoit, Dubuisson, Jean
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9119441/
https://www.ncbi.nlm.nih.gov/pubmed/35587469
http://dx.doi.org/10.1371/journal.ppat.1010498

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9119441/
https://www.ncbi.nlm.nih.gov/pubmed/35587469
http://dx.doi.org/10.1371/journal.ppat.1010498

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