Cargando…
Dose-dependent impact of statin therapy intensity on circulating progenitor cells in patients undergoing percutaneous coronary intervention for the treatment of acute versus chronic coronary syndrome
BACKGROUND: By low-density lipoprotein (LDL) reduction, statins play an important role in cardiovascular risk modification. Incompletely understood pleiotropic statin effects include vasoprotection that might originate from mobilisation and differentiation of vascular progenitor cells. Data on the p...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9119492/ https://www.ncbi.nlm.nih.gov/pubmed/35587929 http://dx.doi.org/10.1371/journal.pone.0267433 |
_version_ | 1784710713116196864 |
---|---|
author | Florescu, Roberta Liehn, Elisa Schaaps, Nicole Schröder, Jörg Almalla, Mohammad Mause, Sebastian Cornelissen, Anne Vogt, Felix |
author_facet | Florescu, Roberta Liehn, Elisa Schaaps, Nicole Schröder, Jörg Almalla, Mohammad Mause, Sebastian Cornelissen, Anne Vogt, Felix |
author_sort | Florescu, Roberta |
collection | PubMed |
description | BACKGROUND: By low-density lipoprotein (LDL) reduction, statins play an important role in cardiovascular risk modification. Incompletely understood pleiotropic statin effects include vasoprotection that might originate from mobilisation and differentiation of vascular progenitor cells. Data on the potentially differential impact of statin treatment intensity on circulating progenitor cells in patients undergoing percutaneous coronary intervention (PCI) are scarce. This study examines the potential association of different permanent statin treatment regimens on circulating progenitor cells in patients with coronary syndrome. METHODS AND RESULTS: In a monocentric prospective all-comers study, 105 consecutive cases scheduled for coronary angiography due to either (A) non-invasive proof of ischemia and chronic coronary syndrome (CCS) or (B) troponin-positive acute coronary syndrome (ACS) were included. According to the 2018 American College of Cardiology Guidelines on Blood Cholesterol, patients were clustered depending on their respective permanent statin treatment regimen in either a high- to moderate-intensity statin treatment (HIST) or a low-intensity statin treatment (LIST) group. Baseline characteristics including LDL levels were comparable. From blood drawn at the time of PCI, peripheral blood mononuclear cells were isolated, cultivated and counted and, by density gradient centrifugation, levels of circulating progenitor cells were determined using fluorescence-activated cell sorting (FACS) analysis. In ACS patients both absolute and relative numbers of circulating early-outgrowth endothelial progenitor cells (EPCs) concurrently were significantly lower in the HIST group as compared to the LIST group. This effect was more pronounced in ACS patients than in CCS patients. Both in ACS and CCS patients, HIST caused a significant reduction of the number of circulating SMPCs. CONCLUSIONS: In patients undergoing PCI, a dose intensity-dependent and LDL level-independent pro-differentiating vasoprotective pleiotropic capacity of statins for EPC and SMPC is demonstrated. |
format | Online Article Text |
id | pubmed-9119492 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-91194922022-05-20 Dose-dependent impact of statin therapy intensity on circulating progenitor cells in patients undergoing percutaneous coronary intervention for the treatment of acute versus chronic coronary syndrome Florescu, Roberta Liehn, Elisa Schaaps, Nicole Schröder, Jörg Almalla, Mohammad Mause, Sebastian Cornelissen, Anne Vogt, Felix PLoS One Research Article BACKGROUND: By low-density lipoprotein (LDL) reduction, statins play an important role in cardiovascular risk modification. Incompletely understood pleiotropic statin effects include vasoprotection that might originate from mobilisation and differentiation of vascular progenitor cells. Data on the potentially differential impact of statin treatment intensity on circulating progenitor cells in patients undergoing percutaneous coronary intervention (PCI) are scarce. This study examines the potential association of different permanent statin treatment regimens on circulating progenitor cells in patients with coronary syndrome. METHODS AND RESULTS: In a monocentric prospective all-comers study, 105 consecutive cases scheduled for coronary angiography due to either (A) non-invasive proof of ischemia and chronic coronary syndrome (CCS) or (B) troponin-positive acute coronary syndrome (ACS) were included. According to the 2018 American College of Cardiology Guidelines on Blood Cholesterol, patients were clustered depending on their respective permanent statin treatment regimen in either a high- to moderate-intensity statin treatment (HIST) or a low-intensity statin treatment (LIST) group. Baseline characteristics including LDL levels were comparable. From blood drawn at the time of PCI, peripheral blood mononuclear cells were isolated, cultivated and counted and, by density gradient centrifugation, levels of circulating progenitor cells were determined using fluorescence-activated cell sorting (FACS) analysis. In ACS patients both absolute and relative numbers of circulating early-outgrowth endothelial progenitor cells (EPCs) concurrently were significantly lower in the HIST group as compared to the LIST group. This effect was more pronounced in ACS patients than in CCS patients. Both in ACS and CCS patients, HIST caused a significant reduction of the number of circulating SMPCs. CONCLUSIONS: In patients undergoing PCI, a dose intensity-dependent and LDL level-independent pro-differentiating vasoprotective pleiotropic capacity of statins for EPC and SMPC is demonstrated. Public Library of Science 2022-05-19 /pmc/articles/PMC9119492/ /pubmed/35587929 http://dx.doi.org/10.1371/journal.pone.0267433 Text en © 2022 Florescu et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Florescu, Roberta Liehn, Elisa Schaaps, Nicole Schröder, Jörg Almalla, Mohammad Mause, Sebastian Cornelissen, Anne Vogt, Felix Dose-dependent impact of statin therapy intensity on circulating progenitor cells in patients undergoing percutaneous coronary intervention for the treatment of acute versus chronic coronary syndrome |
title | Dose-dependent impact of statin therapy intensity on circulating progenitor cells in patients undergoing percutaneous coronary intervention for the treatment of acute versus chronic coronary syndrome |
title_full | Dose-dependent impact of statin therapy intensity on circulating progenitor cells in patients undergoing percutaneous coronary intervention for the treatment of acute versus chronic coronary syndrome |
title_fullStr | Dose-dependent impact of statin therapy intensity on circulating progenitor cells in patients undergoing percutaneous coronary intervention for the treatment of acute versus chronic coronary syndrome |
title_full_unstemmed | Dose-dependent impact of statin therapy intensity on circulating progenitor cells in patients undergoing percutaneous coronary intervention for the treatment of acute versus chronic coronary syndrome |
title_short | Dose-dependent impact of statin therapy intensity on circulating progenitor cells in patients undergoing percutaneous coronary intervention for the treatment of acute versus chronic coronary syndrome |
title_sort | dose-dependent impact of statin therapy intensity on circulating progenitor cells in patients undergoing percutaneous coronary intervention for the treatment of acute versus chronic coronary syndrome |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9119492/ https://www.ncbi.nlm.nih.gov/pubmed/35587929 http://dx.doi.org/10.1371/journal.pone.0267433 |
work_keys_str_mv | AT florescuroberta dosedependentimpactofstatintherapyintensityoncirculatingprogenitorcellsinpatientsundergoingpercutaneouscoronaryinterventionforthetreatmentofacuteversuschroniccoronarysyndrome AT liehnelisa dosedependentimpactofstatintherapyintensityoncirculatingprogenitorcellsinpatientsundergoingpercutaneouscoronaryinterventionforthetreatmentofacuteversuschroniccoronarysyndrome AT schaapsnicole dosedependentimpactofstatintherapyintensityoncirculatingprogenitorcellsinpatientsundergoingpercutaneouscoronaryinterventionforthetreatmentofacuteversuschroniccoronarysyndrome AT schroderjorg dosedependentimpactofstatintherapyintensityoncirculatingprogenitorcellsinpatientsundergoingpercutaneouscoronaryinterventionforthetreatmentofacuteversuschroniccoronarysyndrome AT almallamohammad dosedependentimpactofstatintherapyintensityoncirculatingprogenitorcellsinpatientsundergoingpercutaneouscoronaryinterventionforthetreatmentofacuteversuschroniccoronarysyndrome AT mausesebastian dosedependentimpactofstatintherapyintensityoncirculatingprogenitorcellsinpatientsundergoingpercutaneouscoronaryinterventionforthetreatmentofacuteversuschroniccoronarysyndrome AT cornelissenanne dosedependentimpactofstatintherapyintensityoncirculatingprogenitorcellsinpatientsundergoingpercutaneouscoronaryinterventionforthetreatmentofacuteversuschroniccoronarysyndrome AT vogtfelix dosedependentimpactofstatintherapyintensityoncirculatingprogenitorcellsinpatientsundergoingpercutaneouscoronaryinterventionforthetreatmentofacuteversuschroniccoronarysyndrome |