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Comparison of herpes simplex virus 1 genomic diversity between adult sexual transmission partners with genital infection
Herpes simplex virus (HSV) causes chronic infection in the human host, characterized by self-limited episodes of mucosal shedding and lesional disease, with latent infection of neuronal ganglia. The epidemiology of genital herpes has undergone a significant transformation over the past two decades,...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9119503/ https://www.ncbi.nlm.nih.gov/pubmed/35587470 http://dx.doi.org/10.1371/journal.ppat.1010437 |
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author | Rathbun, Molly M. Shipley, Mackenzie M. Bowen, Christopher D. Selke, Stacy Wald, Anna Johnston, Christine Szpara, Moriah L. |
author_facet | Rathbun, Molly M. Shipley, Mackenzie M. Bowen, Christopher D. Selke, Stacy Wald, Anna Johnston, Christine Szpara, Moriah L. |
author_sort | Rathbun, Molly M. |
collection | PubMed |
description | Herpes simplex virus (HSV) causes chronic infection in the human host, characterized by self-limited episodes of mucosal shedding and lesional disease, with latent infection of neuronal ganglia. The epidemiology of genital herpes has undergone a significant transformation over the past two decades, with the emergence of HSV-1 as a leading cause of first-episode genital herpes in many countries. Though dsDNA viruses are not expected to mutate quickly, it is not yet known to what degree the HSV-1 viral population in a natural host adapts over time, or how often viral population variants are transmitted between hosts. This study provides a comparative genomics analysis for 33 temporally-sampled oral and genital HSV-1 genomes derived from five adult sexual transmission pairs. We found that transmission pairs harbored consensus-level viral genomes with near-complete conservation of nucleotide identity. Examination of within-host minor variants in the viral population revealed both shared and unique patterns of genetic diversity between partners, and between anatomical niches. Additionally, genetic drift was detected from spatiotemporally separated samples in as little as three days. These data expand our prior understanding of the complex interaction between HSV-1 genomics and population dynamics after transmission to new infected persons. |
format | Online Article Text |
id | pubmed-9119503 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-91195032022-05-20 Comparison of herpes simplex virus 1 genomic diversity between adult sexual transmission partners with genital infection Rathbun, Molly M. Shipley, Mackenzie M. Bowen, Christopher D. Selke, Stacy Wald, Anna Johnston, Christine Szpara, Moriah L. PLoS Pathog Research Article Herpes simplex virus (HSV) causes chronic infection in the human host, characterized by self-limited episodes of mucosal shedding and lesional disease, with latent infection of neuronal ganglia. The epidemiology of genital herpes has undergone a significant transformation over the past two decades, with the emergence of HSV-1 as a leading cause of first-episode genital herpes in many countries. Though dsDNA viruses are not expected to mutate quickly, it is not yet known to what degree the HSV-1 viral population in a natural host adapts over time, or how often viral population variants are transmitted between hosts. This study provides a comparative genomics analysis for 33 temporally-sampled oral and genital HSV-1 genomes derived from five adult sexual transmission pairs. We found that transmission pairs harbored consensus-level viral genomes with near-complete conservation of nucleotide identity. Examination of within-host minor variants in the viral population revealed both shared and unique patterns of genetic diversity between partners, and between anatomical niches. Additionally, genetic drift was detected from spatiotemporally separated samples in as little as three days. These data expand our prior understanding of the complex interaction between HSV-1 genomics and population dynamics after transmission to new infected persons. Public Library of Science 2022-05-19 /pmc/articles/PMC9119503/ /pubmed/35587470 http://dx.doi.org/10.1371/journal.ppat.1010437 Text en © 2022 Rathbun et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Rathbun, Molly M. Shipley, Mackenzie M. Bowen, Christopher D. Selke, Stacy Wald, Anna Johnston, Christine Szpara, Moriah L. Comparison of herpes simplex virus 1 genomic diversity between adult sexual transmission partners with genital infection |
title | Comparison of herpes simplex virus 1 genomic diversity between adult sexual transmission partners with genital infection |
title_full | Comparison of herpes simplex virus 1 genomic diversity between adult sexual transmission partners with genital infection |
title_fullStr | Comparison of herpes simplex virus 1 genomic diversity between adult sexual transmission partners with genital infection |
title_full_unstemmed | Comparison of herpes simplex virus 1 genomic diversity between adult sexual transmission partners with genital infection |
title_short | Comparison of herpes simplex virus 1 genomic diversity between adult sexual transmission partners with genital infection |
title_sort | comparison of herpes simplex virus 1 genomic diversity between adult sexual transmission partners with genital infection |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9119503/ https://www.ncbi.nlm.nih.gov/pubmed/35587470 http://dx.doi.org/10.1371/journal.ppat.1010437 |
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