MDM2 E3 ligase activity is essential for p53 regulation and cell cycle integrity

MDM2 and MDM4 are key regulators of p53 and function as oncogenes when aberrantly expressed. MDM2 and MDM4 partner to suppress p53 transcriptional transactivation and polyubiquitinate p53 for degradation. The importance of MDM2 E3-ligase-mediated p53 regulation remains controversial. To resolve this...

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Detalles Bibliográficos
Autores principales: Chinnam, Meenalakshmi, Xu, Chao, Lama, Rati, Zhang, Xiaojing, Cedeno, Carlos D., Wang, Yanqing, Stablewski, Aimee B., Goodrich, David W., Wang, Xinjiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9119546/
https://www.ncbi.nlm.nih.gov/pubmed/35588102
http://dx.doi.org/10.1371/journal.pgen.1010171

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