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Prognostic value of nutritional parameters in systolic heart failure with renal dysfunction

Although it is known that assessment and management of the nutritional status of patients are important for treatment of patients with heart failure (HF), there are currently no established indicators. Therefore, we investigated the effects of nutritional parameters as well as conventional parameter...

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Autores principales: Doi, Takahiro, Noto, Takahiro, Mita, Tomohiro, Nagahara, Daigo, Yuda, Satoshi, Hashimoto, Akiyoshi, Nakata, Tomoaki, Nakajima, Kenichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9119558/
https://www.ncbi.nlm.nih.gov/pubmed/35587474
http://dx.doi.org/10.1371/journal.pone.0266839
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author Doi, Takahiro
Noto, Takahiro
Mita, Tomohiro
Nagahara, Daigo
Yuda, Satoshi
Hashimoto, Akiyoshi
Nakata, Tomoaki
Nakajima, Kenichi
author_facet Doi, Takahiro
Noto, Takahiro
Mita, Tomohiro
Nagahara, Daigo
Yuda, Satoshi
Hashimoto, Akiyoshi
Nakata, Tomoaki
Nakajima, Kenichi
author_sort Doi, Takahiro
collection PubMed
description Although it is known that assessment and management of the nutritional status of patients are important for treatment of patients with heart failure (HF), there are currently no established indicators. Therefore, we investigated the effects of nutritional parameters as well as conventional parameters on the prognosis of HF patients. A total of 1954 consecutive HF patients with left ventricular ejection fraction (LVEF) less than 50% were enrolled in this study. Transthoracic echocardiography was performed and conventional parameters for HF patients and parameters to assess nutritional status were measured in all patients. Patients were followed up with a primary endpoint of lethal cardiac events (CEs) for 30.2 months. During the follow-up period, cardiac events were documented in 619 HF patients. The CEs group had a lower level of cholinesterase (201.5U/L vs 265.2U/L, P <0.0001), lower estimated GFR (35.2 ml/min/1.73m(2) vs 50.3ml/min/1.73m(2), P< 0.0001), and lower Geriatric Nutritional Risk Index (GNRI) (91.9 vs 100.0, P< 0.0001) than those in the non-CEs group. Serum cholinesterase, estimated GFR, and GNRI were identified as significant prognostic determinants in multivariate analysis. ROC analyses revealed cut-off values of serum cholinesterase, estimated GFR, and GNRI of 229U/L, 34.2 ml/min/1.73m(2), and 95.6, respectively, for identifying high-risk HF patients. HF patients with serum cholinesterase< 229U/L, estimated GFR<34.3 ml/min/1.73m(2), and GNRI< 95.6 had a significantly greater rate of CEs than that in the other patients (P<0.0001). Low serum cholinesterase and low GNRI can predict cardiac mortality risk in systolic HF patients with renal dysfunction.
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spelling pubmed-91195582022-05-20 Prognostic value of nutritional parameters in systolic heart failure with renal dysfunction Doi, Takahiro Noto, Takahiro Mita, Tomohiro Nagahara, Daigo Yuda, Satoshi Hashimoto, Akiyoshi Nakata, Tomoaki Nakajima, Kenichi PLoS One Research Article Although it is known that assessment and management of the nutritional status of patients are important for treatment of patients with heart failure (HF), there are currently no established indicators. Therefore, we investigated the effects of nutritional parameters as well as conventional parameters on the prognosis of HF patients. A total of 1954 consecutive HF patients with left ventricular ejection fraction (LVEF) less than 50% were enrolled in this study. Transthoracic echocardiography was performed and conventional parameters for HF patients and parameters to assess nutritional status were measured in all patients. Patients were followed up with a primary endpoint of lethal cardiac events (CEs) for 30.2 months. During the follow-up period, cardiac events were documented in 619 HF patients. The CEs group had a lower level of cholinesterase (201.5U/L vs 265.2U/L, P <0.0001), lower estimated GFR (35.2 ml/min/1.73m(2) vs 50.3ml/min/1.73m(2), P< 0.0001), and lower Geriatric Nutritional Risk Index (GNRI) (91.9 vs 100.0, P< 0.0001) than those in the non-CEs group. Serum cholinesterase, estimated GFR, and GNRI were identified as significant prognostic determinants in multivariate analysis. ROC analyses revealed cut-off values of serum cholinesterase, estimated GFR, and GNRI of 229U/L, 34.2 ml/min/1.73m(2), and 95.6, respectively, for identifying high-risk HF patients. HF patients with serum cholinesterase< 229U/L, estimated GFR<34.3 ml/min/1.73m(2), and GNRI< 95.6 had a significantly greater rate of CEs than that in the other patients (P<0.0001). Low serum cholinesterase and low GNRI can predict cardiac mortality risk in systolic HF patients with renal dysfunction. Public Library of Science 2022-05-19 /pmc/articles/PMC9119558/ /pubmed/35587474 http://dx.doi.org/10.1371/journal.pone.0266839 Text en © 2022 Doi et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Doi, Takahiro
Noto, Takahiro
Mita, Tomohiro
Nagahara, Daigo
Yuda, Satoshi
Hashimoto, Akiyoshi
Nakata, Tomoaki
Nakajima, Kenichi
Prognostic value of nutritional parameters in systolic heart failure with renal dysfunction
title Prognostic value of nutritional parameters in systolic heart failure with renal dysfunction
title_full Prognostic value of nutritional parameters in systolic heart failure with renal dysfunction
title_fullStr Prognostic value of nutritional parameters in systolic heart failure with renal dysfunction
title_full_unstemmed Prognostic value of nutritional parameters in systolic heart failure with renal dysfunction
title_short Prognostic value of nutritional parameters in systolic heart failure with renal dysfunction
title_sort prognostic value of nutritional parameters in systolic heart failure with renal dysfunction
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9119558/
https://www.ncbi.nlm.nih.gov/pubmed/35587474
http://dx.doi.org/10.1371/journal.pone.0266839
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