Lipids and genes: Regulatory roles of lipids in RNA expression

Nuclear lipid metabolism and metabolites play important roles in regulation of lipid–lipid, lipid–gene, lipid–chromatin, lipid–membrane and lipid–protein interactions to maintain the nuclear microenvironment, three‐dimensional chromatin architecture, gene expression and transcription and biological function. This Editorial highlights the value of lipid–gene interaction in the identification and development of biomarkers and targets and emphasizes the significance of inter‐regulation between lipids and genes in innovation and application of precise therapies for patients. Regulatory functions of nuclear lipid dynamics and biophysics modify transcriptomic expression, and modification (lipotranscriptome) can be a new approach for discovery and development of disease‐specific diagnoses and therapies, although there are several challenges to be overcome. Better understanding of how lipid‐based changes of nuclear functions and transcriptomic profiles modify clinical phenomes will provide new insights to understand molecular mechanisms of diseases and to develop spatiotemporal molecular medicine diagnostics and therapeutics.