Redox regulation of PTPN22 affects the severity of T-cell-dependent autoimmune inflammation

Chronic autoimmune diseases are associated with mutations in PTPN22, a modifier of T cell receptor (TCR) signaling. As with all protein tyrosine phosphatases, the activity of PTPN22 is redox regulated, but if or how such regulation can modulate inflammatory pathways in vivo is not known. To determin...

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Detalles Bibliográficos
Autores principales: James, Jaime, Chen, Yifei, Hernandez, Clara M, Forster, Florian, Dagnell, Markus, Cheng, Qing, Saei, Amir A, Gharibi, Hassan, Lahore, Gonzalo Fernandez, Åstrand, Annika, Malhotra, Rajneesh, Malissen, Bernard, Zubarev, Roman A, Arnér, Elias SJ, Holmdahl, Rikard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Immunology and Inflammation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9119677/
https://www.ncbi.nlm.nih.gov/pubmed/35587260
http://dx.doi.org/10.7554/eLife.74549

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