Brucella activates the host RIDD pathway to subvert BLOS1-directed immune defense

The phagocytosis and destruction of pathogens in lysosomes constitute central elements of innate immune defense. Here, we show that Brucella, the causative agent of brucellosis, the most prevalent bacterial zoonosis globally, subverts this immune defense pathway by activating regulated IRE1α-depende...

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Detalles Bibliográficos
Autores principales: Wells, Kelsey Michelle, He, Kai, Pandey, Aseem, Cabello, Ana, Zhang, Dongmei, Yang, Jing, Gomez, Gabriel, Liu, Yue, Chang, Haowu, Li, Xueqiang, Zhang, Hao, Feng, Xuehuang, da Costa, Luciana Fachini, Metz, Richard, Johnson, Charles D, Martin, Cameron Lee, Skrobarczyk, Jill, Berghman, Luc R, Patrick, Kristin L, Leibowitz, Julian, Ficht, Allison, Sze, Sing-Hoi, Song, Jianxun, Qian, Xiaoning, Qin, Qing-Ming, Ficht, Thomas A, de Figueiredo, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Microbiology and Infectious Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9119680/
https://www.ncbi.nlm.nih.gov/pubmed/35587649
http://dx.doi.org/10.7554/eLife.73625

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