Unequal burden of Zika-associated microcephaly among populations with public and private healthcare in Salvador, Brazil

OBJECTIVES: To describe the differences in clinical presentation and relative disease burden of congenital Zika syndrome (CZS)-associated microcephaly at 2 large hospitals in Salvador, Brazil that serve patients of different socioeconomic status (SES). METHODS: Clinical and serologic data were colle...

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Detalles Bibliográficos
Autores principales: Aromolaran, Adeolu, Araujo, Katiaci, Ladines-Lim, Joseph B., Nery, Nivison, do Rosário, Mateus S., Rastely, Valmir N., Archanjo, Gracinda, Daltro, Dina, Carvalho, Gustavo Baltazar da Silveira, Pimentel, Kleber, de Almeida, João Ricardo Maltez, de Siqueira, Isadora Cristina, Ribeiro, Hugo C., Oliveira-Filho, Jamary, de Oliveira, Daiana, Henriques, Daniele F., Rodrigues, Sueli G., Vasconcelos, Pedro F. da Costa, de Almeida, Antonio R.P., Sacramento, Gielson A., Cruz, Jaqueline S., Sarno, Manoel, Freitas, Bruno de Paula, Mattos, Adriana, Khouri, Ricardo, Reis, Mitermayer G., Ko, Albert I., Costa, Federico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9119857/
https://www.ncbi.nlm.nih.gov/pubmed/35470025
http://dx.doi.org/10.1016/j.ijid.2022.04.030
Descripción
Sumario:OBJECTIVES: To describe the differences in clinical presentation and relative disease burden of congenital Zika syndrome (CZS)-associated microcephaly at 2 large hospitals in Salvador, Brazil that serve patients of different socioeconomic status (SES). METHODS: Clinical and serologic data were collected prospectively from pregnant women and their infants, who delivered at 2 study centers during the 2015–2016 Zika virus (ZIKV) epidemic in Salvador, Brazil. RESULTS: Pregnant women from Salvador, Brazil delivering in a low SES hospital had 3 times higher ZIKV exposure rate than women at a high SES hospital. However, different SES hospitals had similar prevalence of infants with CZS-associated microcephaly (10% vs 6%, p = 0.16) after controlling for ZIKV exposure in their mothers. CONCLUSIONS: Our study supports the positive association between low SES, high maternal ZIKV exposure, and high rates of CZS-associated microcephaly.

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