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VacSIM: Learning effective strategies for COVID-19 vaccine distribution using reinforcement learning

A COVID-19 vaccine is our best bet for mitigating the ongoing onslaught of the pandemic. However, vaccine is also expected to be a limited resource. An optimal allocation strategy, especially in countries with access inequities and temporal separation of hot-spots, might be an effective way of halti...

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Autores principales: Awasthi, Raghav, Guliani, Keerat Kaur, Khan, Saif Ahmad, Vashishtha, Aniket, Gill, Mehrab Singh, Bhatt, Arshita, Nagori, Aditya, Gupta, Aniket, Kumaraguru, Ponnurangam, Sethi, Tavpritesh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. Published by Elsevier B.V. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9119863/
https://www.ncbi.nlm.nih.gov/pubmed/35610985
http://dx.doi.org/10.1016/j.ibmed.2022.100060
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author Awasthi, Raghav
Guliani, Keerat Kaur
Khan, Saif Ahmad
Vashishtha, Aniket
Gill, Mehrab Singh
Bhatt, Arshita
Nagori, Aditya
Gupta, Aniket
Kumaraguru, Ponnurangam
Sethi, Tavpritesh
author_facet Awasthi, Raghav
Guliani, Keerat Kaur
Khan, Saif Ahmad
Vashishtha, Aniket
Gill, Mehrab Singh
Bhatt, Arshita
Nagori, Aditya
Gupta, Aniket
Kumaraguru, Ponnurangam
Sethi, Tavpritesh
author_sort Awasthi, Raghav
collection PubMed
description A COVID-19 vaccine is our best bet for mitigating the ongoing onslaught of the pandemic. However, vaccine is also expected to be a limited resource. An optimal allocation strategy, especially in countries with access inequities and temporal separation of hot-spots, might be an effective way of halting the disease spread. We approach this problem by proposing a novel pipeline VacSIM that dovetails Deep Reinforcement Learning models into a Contextual Bandits approach for optimizing the distribution of COVID-19 vaccine. Whereas the Reinforcement Learning models suggest better actions and rewards, Contextual Bandits allow online modifications that may need to be implemented on a day-to-day basis in the real world scenario. We evaluate this framework against a naive allocation approach of distributing vaccine proportional to the incidence of COVID-19 cases in five different States across India (Assam, Delhi, Jharkhand, Maharashtra and Nagaland) and demonstrate up to 9039 potential infections prevented and a significant increase in the efficacy of limiting the spread over a period of 45 days through the VacSIM approach. Our models and the platform are extensible to all states of India and potentially across the globe. We also propose novel evaluation strategies including standard compartmental model-based projections and a causality-preserving evaluation of our model. Since all models carry assumptions that may need to be tested in various contexts, we open source our model VacSIM and contribute a new reinforcement learning environment compatible with OpenAI gym to make it extensible for real-world applications across the globe.
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spelling pubmed-91198632022-05-20 VacSIM: Learning effective strategies for COVID-19 vaccine distribution using reinforcement learning Awasthi, Raghav Guliani, Keerat Kaur Khan, Saif Ahmad Vashishtha, Aniket Gill, Mehrab Singh Bhatt, Arshita Nagori, Aditya Gupta, Aniket Kumaraguru, Ponnurangam Sethi, Tavpritesh Intell Based Med Article A COVID-19 vaccine is our best bet for mitigating the ongoing onslaught of the pandemic. However, vaccine is also expected to be a limited resource. An optimal allocation strategy, especially in countries with access inequities and temporal separation of hot-spots, might be an effective way of halting the disease spread. We approach this problem by proposing a novel pipeline VacSIM that dovetails Deep Reinforcement Learning models into a Contextual Bandits approach for optimizing the distribution of COVID-19 vaccine. Whereas the Reinforcement Learning models suggest better actions and rewards, Contextual Bandits allow online modifications that may need to be implemented on a day-to-day basis in the real world scenario. We evaluate this framework against a naive allocation approach of distributing vaccine proportional to the incidence of COVID-19 cases in five different States across India (Assam, Delhi, Jharkhand, Maharashtra and Nagaland) and demonstrate up to 9039 potential infections prevented and a significant increase in the efficacy of limiting the spread over a period of 45 days through the VacSIM approach. Our models and the platform are extensible to all states of India and potentially across the globe. We also propose novel evaluation strategies including standard compartmental model-based projections and a causality-preserving evaluation of our model. Since all models carry assumptions that may need to be tested in various contexts, we open source our model VacSIM and contribute a new reinforcement learning environment compatible with OpenAI gym to make it extensible for real-world applications across the globe. The Authors. Published by Elsevier B.V. 2022 2022-05-20 /pmc/articles/PMC9119863/ /pubmed/35610985 http://dx.doi.org/10.1016/j.ibmed.2022.100060 Text en © 2022 The Authors Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Awasthi, Raghav
Guliani, Keerat Kaur
Khan, Saif Ahmad
Vashishtha, Aniket
Gill, Mehrab Singh
Bhatt, Arshita
Nagori, Aditya
Gupta, Aniket
Kumaraguru, Ponnurangam
Sethi, Tavpritesh
VacSIM: Learning effective strategies for COVID-19 vaccine distribution using reinforcement learning
title VacSIM: Learning effective strategies for COVID-19 vaccine distribution using reinforcement learning
title_full VacSIM: Learning effective strategies for COVID-19 vaccine distribution using reinforcement learning
title_fullStr VacSIM: Learning effective strategies for COVID-19 vaccine distribution using reinforcement learning
title_full_unstemmed VacSIM: Learning effective strategies for COVID-19 vaccine distribution using reinforcement learning
title_short VacSIM: Learning effective strategies for COVID-19 vaccine distribution using reinforcement learning
title_sort vacsim: learning effective strategies for covid-19 vaccine distribution using reinforcement learning
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9119863/
https://www.ncbi.nlm.nih.gov/pubmed/35610985
http://dx.doi.org/10.1016/j.ibmed.2022.100060
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