Cargando…
Coagulation in gout: is there a link with disease activity?
OBJECTIVE: To investigate the coagulation system in gout patients and associations between disease activity and levels of coagulation markers. METHODS: A prospective cohort study was performed with data from 30 Dutch gout patients. Levels of coagulation markers including APTT, PT, D-dimer, prothromb...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9119879/ https://www.ncbi.nlm.nih.gov/pubmed/35102534 http://dx.doi.org/10.1007/s10067-022-06047-9 |
_version_ | 1784710789067702272 |
---|---|
author | Vedder, Daisy Gerritsen, Martijn Meijers, Joost C. M. Nurmohamed, Michael T. |
author_facet | Vedder, Daisy Gerritsen, Martijn Meijers, Joost C. M. Nurmohamed, Michael T. |
author_sort | Vedder, Daisy |
collection | PubMed |
description | OBJECTIVE: To investigate the coagulation system in gout patients and associations between disease activity and levels of coagulation markers. METHODS: A prospective cohort study was performed with data from 30 Dutch gout patients. Levels of coagulation markers including APTT, PT, D-dimer, prothrombin F1 + 2, von Willebrand factor, and thrombin generation parameters were analyzed at baseline and 1-year visit. These markers were related to clinical markers of gout disease activity including the Gout Activity Score (GAS). Our hypothesis was that patients with gout and active disease have increased levels of coagulation markers and that a decrease in disease activity would lead to normalization of coagulation activity. RESULTS: A higher GAS was associated with increased levels of thrombin generation parameters including ETP (ß = 0.48, p = 0.01), peak thrombin (ß = 0.60, p = 0.001), and velocity index (ß = 0.57, p = 0.002). Tophaceous gout and higher SUA levels were associated with thrombin generation parameters. After 1 year, thrombin generation parameters showed a small procoagulant trend despite a moderate decrease in disease activity. Prospectively measured changes in disease activity according to the GAS were not associated with any of the coagulation markers. CONCLUSION: Patients with active gout have higher levels of thrombin generation markers, indicating a link between disease activity and coagulation. A change in disease activity after 1 year was not associated with significant changes in coagulation markers, probably due to prolonged low-grade inflammation. Future studies should focus on levels of coagulation markers in comparison with the general population and the effect of adequate gout treatment. |
format | Online Article Text |
id | pubmed-9119879 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-91198792022-05-21 Coagulation in gout: is there a link with disease activity? Vedder, Daisy Gerritsen, Martijn Meijers, Joost C. M. Nurmohamed, Michael T. Clin Rheumatol Original Article OBJECTIVE: To investigate the coagulation system in gout patients and associations between disease activity and levels of coagulation markers. METHODS: A prospective cohort study was performed with data from 30 Dutch gout patients. Levels of coagulation markers including APTT, PT, D-dimer, prothrombin F1 + 2, von Willebrand factor, and thrombin generation parameters were analyzed at baseline and 1-year visit. These markers were related to clinical markers of gout disease activity including the Gout Activity Score (GAS). Our hypothesis was that patients with gout and active disease have increased levels of coagulation markers and that a decrease in disease activity would lead to normalization of coagulation activity. RESULTS: A higher GAS was associated with increased levels of thrombin generation parameters including ETP (ß = 0.48, p = 0.01), peak thrombin (ß = 0.60, p = 0.001), and velocity index (ß = 0.57, p = 0.002). Tophaceous gout and higher SUA levels were associated with thrombin generation parameters. After 1 year, thrombin generation parameters showed a small procoagulant trend despite a moderate decrease in disease activity. Prospectively measured changes in disease activity according to the GAS were not associated with any of the coagulation markers. CONCLUSION: Patients with active gout have higher levels of thrombin generation markers, indicating a link between disease activity and coagulation. A change in disease activity after 1 year was not associated with significant changes in coagulation markers, probably due to prolonged low-grade inflammation. Future studies should focus on levels of coagulation markers in comparison with the general population and the effect of adequate gout treatment. Springer International Publishing 2022-02-01 2022 /pmc/articles/PMC9119879/ /pubmed/35102534 http://dx.doi.org/10.1007/s10067-022-06047-9 Text en © The Author(s) 2022, corrected publication 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Original Article Vedder, Daisy Gerritsen, Martijn Meijers, Joost C. M. Nurmohamed, Michael T. Coagulation in gout: is there a link with disease activity? |
title | Coagulation in gout: is there a link with disease activity? |
title_full | Coagulation in gout: is there a link with disease activity? |
title_fullStr | Coagulation in gout: is there a link with disease activity? |
title_full_unstemmed | Coagulation in gout: is there a link with disease activity? |
title_short | Coagulation in gout: is there a link with disease activity? |
title_sort | coagulation in gout: is there a link with disease activity? |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9119879/ https://www.ncbi.nlm.nih.gov/pubmed/35102534 http://dx.doi.org/10.1007/s10067-022-06047-9 |
work_keys_str_mv | AT vedderdaisy coagulationingoutistherealinkwithdiseaseactivity AT gerritsenmartijn coagulationingoutistherealinkwithdiseaseactivity AT meijersjoostcm coagulationingoutistherealinkwithdiseaseactivity AT nurmohamedmichaelt coagulationingoutistherealinkwithdiseaseactivity |