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Characterization of neurological disease progression in a canine model of CLN5 neuronal ceroid lipofuscinosis

Golden Retriever dogs with a frameshift variant in CLN5 (c.934_935delAG) suffer from a progressive neurodegenerative disorder analogous to the CLN5 form of neuronal ceroid lipofuscinosis (NCL). Five littermate puppies homozygous for the deletion allele were identified prior to the onset of disease s...

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Detalles Bibliográficos
Autores principales:	Meiman, Elizabeth J., Kick, Grace Robinson, Jensen, Cheryl A., Coates, Joan R., Katz, Martin L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9119968/ https://www.ncbi.nlm.nih.gov/pubmed/35427439 http://dx.doi.org/10.1002/dneu.22878

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