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Ribosome inhibition by C9ORF72-ALS/FTD-associated poly-PR and poly-GR proteins revealed by cryo-EM

Toxic dipeptide-repeat (DPR) proteins are produced from expanded G(4)C(2) repeats in the C9ORF72 gene, the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Two DPR proteins, poly-PR and poly-GR, repress cellular translation but the molecular mechani...

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Detalles Bibliográficos
Autores principales:	Loveland, Anna B., Svidritskiy, Egor, Susorov, Denis, Lee, Soojin, Park, Alexander, Zvornicanin, Sarah, Demo, Gabriel, Gao, Fen-Biao, Korostelev, Andrei A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9120013/ https://www.ncbi.nlm.nih.gov/pubmed/35589706 http://dx.doi.org/10.1038/s41467-022-30418-0

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