Cargando…

TGF-β1/SH2B3 axis regulates anoikis resistance and EMT of lung cancer cells by modulating JAK2/STAT3 and SHP2/Grb2 signaling pathways

The pathogenesis of lung cancer, the most common cancer, is complex and unclear, leading to limited treatment options and poor prognosis. To provide molecular insights into lung cancer development, we investigated the function and underlying mechanism of SH2B3 in the regulation of lung cancer. We in...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Li-Na, Zhang, Zi-Teng, Wang, Li, Wei, Hai-Xiang, Zhang, Tao, Zhang, Li-Ming, Lin, Hang, Zhang, Heng, Wang, Shao-Qiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9120066/ https://www.ncbi.nlm.nih.gov/pubmed/35589677 http://dx.doi.org/10.1038/s41419-022-04890-x

Ejemplares similares

Grb2 binding induces phosphorylation-independent activation of Shp2
por: Lin, Chi-Chuan, et al.
Publicado: (2021)

Targeting the Interaction between the SH3 Domain of Grb2 and Gab2
por: Malagrinò, Francesca, et al.
Publicado: (2020)

Osteosarcoma cell proliferation suppression via SHP-2-mediated inactivation of the JAK/STAT3 pathway by tubocapsenolide A
por: Zhu, Dongrong, et al.
Publicado: (2021)

CAFs enhance paclitaxel resistance by inducing EMT through the IL-6/JAK2/STAT3 pathway
por: Wang, Linlin, et al.
Publicado: (2018)

The Role of LNK (SH2B3) in the Regulation of JAK-STAT Signalling in Haematopoiesis
por: Morris, Rhiannon, et al.
Publicado: (2021)

Grb2 controls phosphorylation of FGFR2 by inhibiting receptor kinase and Shp2 phosphatase activity
por: Ahmed, Zamal, et al.
Publicado: (2013)

Coupling of Gab1 to C-Met, Grb2, and Shp2 Mediates Biological Responses
por: Schaeper, Ute, et al.
Publicado: (2000)

Abnormal repression of SHP-1, SHP-2 and SOCS-1 transcription sustains the activation of the JAK/STAT3 pathway and the progression of the disease in multiple myeloma
por: Beldi-Ferchiou, Asma, et al.
Publicado: (2017)

Grb2 carboxyl-terminal SH3 domain can bivalently associate with two ligands, in an SH3 dependent manner
por: Arya, Richa, et al.
Publicado: (2017)

The tyrosine phosphatase SHP2 controls TGFβ-induced STAT3 signaling to regulate fibroblast activation and fibrosis
por: Zehender, Ariella, et al.
Publicado: (2018)

SHP2, SOCS3 and PIAS3 Expression Patterns in Medulloblastomas: Relevance to STAT3 Activation and Resveratrol-Suppressed STAT3 Signaling
por: Li, Cong, et al.
Publicado: (2016)

Neutrophils Promote Tumor Progression in Oral Squamous Cell Carcinoma by Regulating EMT and JAK2/STAT3 Signaling Through Chemerin
por: Hu, Xiaoyuan, et al.
Publicado: (2022)

Understanding the mechanism of binding between Gab2 and the C terminal SH3 domain from Grb2
por: Toto, Angelo, et al.
Publicado: (2017)

Interaction of SHP-2 SH2 domains with PD-1 ITSM induces PD-1 dimerization and SHP-2 activation
por: Patsoukis, Nikolaos, et al.
Publicado: (2020)

Novel STAT3 Inhibitors Targeting STAT3 Dimerization by Binding to the STAT3 SH2 Domain
por: Hua, Yaping, et al.
Publicado: (2022)

Structural and functional properties of Grb2 SH2 dimer in CD28 binding
por: Hosoe, Yuhi, et al.
Publicado: (2019)

Protein-protein interaction between caveolin-1 and SHP-2 is dependent on the N-SH2 domain of SHP-2
por: Park, Hyunju, et al.
Publicado: (2015)

Fedratinib Attenuates Bleomycin-Induced Pulmonary Fibrosis via the JAK2/STAT3 and TGF-β1 Signaling Pathway
por: Ruan, Hao, et al.
Publicado: (2021)

PKM2 promotes angiotensin‐II‐induced cardiac remodelling by activating TGF‐β/Smad2/3 and Jak2/Stat3 pathways through oxidative stress
por: Zhang, Xiyu, et al.
Publicado: (2021)

GRB2 promotes thymocyte positive selection by facilitating THEMIS-mediated inactivation of SHP1
por: Choi, Seeyoung, et al.
Publicado: (2023)

Interleukin‐29 Accelerates Vascular Calcification via JAK2/STAT3/BMP2 Signaling
por: Hao, Nannan, et al.
Publicado: (2022)

SHP2 associates with nuclear localization of STAT3: significance in progression and prognosis of colorectal cancer
por: Huang, Yan, et al.
Publicado: (2017)

Besides an ITIM/SHP-1-dependent pathway, CD22 collaborates with Grb2 and plasma membrane calcium-ATPase in an ITIM/SHP-1-independent pathway of attenuation of Ca(2+)(i) signal in B cells
por: Chen, Jie, et al.
Publicado: (2016)

Phosphorylation of the multifunctional signal transducer B-cell adaptor protein (BCAP) promotes recruitment of multiple SH2/SH3 proteins including GRB2
por: Lauenstein, Johannes U., et al.
Publicado: (2019)

Sulfatase 2 Affects Polarization of M2 Macrophages through the IL-8/JAK2/STAT3 Pathway in Bladder Cancer
por: Zhang, Wentao, et al.
Publicado: (2022)

The Grb2 splice variant, Grb3-3, is a negative regulator of RAS activation
por: Seiler, Caroline, et al.
Publicado: (2022)

Understanding the Mechanism of Recognition of Gab2 by the N-SH2 Domain of SHP2
por: Visconti, Lorenzo, et al.
Publicado: (2020)

Gp130 Promotes Inflammation via the STAT3/JAK2 Pathway in Allergic Conjunctivitis
por: Bao, Jiayu, et al.
Publicado: (2023)

Icaritin suppresses multiple myeloma, by inhibiting IL-6/JAK2/STAT3
por: Zhu, Shicong, et al.
Publicado: (2015)

Shp2 Plays a Critical Role in IL-6-Induced EMT in Breast Cancer Cells
por: Sun, Xuan, et al.
Publicado: (2017)

Dietary quercetin potentiates the antiproliferative effect of interferon-α in hepatocellular carcinoma cells through activation of JAK/STAT pathway signaling by inhibition of SHP2 phosphatase
por: Igbe, Ighodaro, et al.
Publicado: (2017)

The multi-site docking protein Grb2-associated binder 1 (Gab1) enhances interleukin-6-induced MAPK-pathway activation in an SHP2-, Grb2-, and time-dependent manner
por: Bongartz, Hannes, et al.
Publicado: (2019)

Phosphatase SHP1 impedes mesenchymal stromal cell immunosuppressive capacity modulated by JAK1/STAT3 and P38 signals
por: Jiang, Menghui, et al.
Publicado: (2020)

GRB2 dimerization mediated by SH2 domain-swapping is critical for T cell signaling and cytokine production
por: Sandouk, Aline, et al.
Publicado: (2023)

MicroRNA-216a inhibits the metastasis of gastric cancer cells by targeting JAK2/STAT3-mediated EMT process
por: Tao, Youmao, et al.
Publicado: (2017)

ZnAs@SiO(2) nanoparticles as a potential anti-tumor drug for targeting stemness and epithelial-mesenchymal transition in hepatocellular carcinoma via SHP-1/JAK2/STAT3 signaling
por: Huang, Yongquan, et al.
Publicado: (2019)

Danshen attenuates cartilage injuries in osteoarthritis in vivo and in vitro by activating JAK2/STAT3 and AKT pathways
por: Xu, Xilin, et al.
Publicado: (2017)

Synergistic anti-leukemic activity of imatinib in combination with a small molecule Grb2 SH2 domain binding antagonist
por: Zhang, Manchao, et al.
Publicado: (2013)

PARK2 inhibits osteosarcoma cell growth through the JAK2/STAT3/VEGF signaling pathway
por: Lei, Zhong, et al.
Publicado: (2018)

FANCD2 inhibits ferroptosis by regulating the JAK2/STAT3 pathway in osteosarcoma
por: Li, Xujun, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_9ql90aj3pu3ljqhidf1gk6d4dl