Cargando…
The ubiquitin ligase Cul5 regulates CD4(+) T cell fate choice and allergic inflammation
Antigen encounter directs CD4(+) T cells to differentiate into T helper or regulatory cells. This process focuses the immune response on the invading pathogen and limits tissue damage. Mechanisms that govern T helper cell versus T regulatory cell fate remain poorly understood. Here, we show that the...
Autores principales: | Kumar, Binod, Field, Natania S., Kim, Dale D., Dar, Asif A., Chen, Yanqun, Suresh, Aishwarya, Pastore, Christopher F., Hung, Li-Yin, Porter, Nadia, Sawada, Keisuke, Shah, Palak, Elbulok, Omar, Moser, Emily K., Herbert, De’Broski R., Oliver, Paula M. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9120070/ https://www.ncbi.nlm.nih.gov/pubmed/35589717 http://dx.doi.org/10.1038/s41467-022-30437-x |
Ejemplares similares
-
The E3 ubiquitin ligase Cul4b promotes CD4(+) T cell expansion by aiding the repair of damaged DNA
por: Dar, Asif A., et al.
Publicado: (2021) -
BIK ubiquitination by the E3 ligase Cul5-ASB11 determines cell fate during cellular stress
por: Chen, Fei-Yun, et al.
Publicado: (2019) -
The Mechanism of NEDD8 Activation of CUL5 Ubiquitin E3 Ligases
por: Lumpkin, Ryan J., et al.
Publicado: (2021) -
New strategies to inhibit KEAP1 and the Cul3-based E3 ubiquitin ligases
por: Canning, Peter, et al.
Publicado: (2014) -
Cul3-KLHL20 ubiquitin ligase: physiological functions, stress responses, and disease implications
por: Chen, Hsin-Yi, et al.
Publicado: (2016)