Higher baseline blood glucose is associated with reduced likelihood for successful recanalization in patients with basilar artery occlusion

PURPOSE: Evidence regarding the effect of mechanical thrombectomy (MT) of basilar artery occlusion (BAO) stroke is yet sparse. As successful recanalization has been suggested as major determinant of outcome, the early identification of modifiable factors associated with successful recanalization cou...

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Detalles Bibliográficos
Autores principales: Broocks, Gabriel, Groffmann, Maximilian, Meyer, Lukas, Elsayed, Sarah, Kniep, Helge, Kemmling, Andre, van Horn, Noel, McDonough, Rosalie, Faizy, Tobias D., Bechstein, Matthias, Sporns, Peter, Rusche, Thilo, Schön, Gerhard, Nawabi, Jawed, Fiehler, Jens, Hanning, Uta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Original Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9120087/
https://www.ncbi.nlm.nih.gov/pubmed/34984515
http://dx.doi.org/10.1007/s00415-021-10948-1
Descripción
Sumario:PURPOSE: Evidence regarding the effect of mechanical thrombectomy (MT) of basilar artery occlusion (BAO) stroke is yet sparse. As successful recanalization has been suggested as major determinant of outcome, the early identification of modifiable factors associated with successful recanalization could be of importance to improve functional outcome. Hyperglycemia has been associated with enhanced thrombin generation and unfavorably altered clot features. OBJECTIVE: We hypothesized that serum baseline glucose is associated with likelihood of vessel recanalization mediated by collateral quality and clot burden in BAO stroke. METHODS: BAO stroke patients who received multimodal CT on admission were analyzed. The association of vessel recanalization defined using modified Thrombolysis in cerebral infarction scale (mTICI) scores 2b-3, and baseline imaging and clinical parameters were tested in logistic regression analyses. Collateral quality and clot burden were evaluated using the Basilar Artery on CT-Angiography (BATMAN) score. RESULTS: Out of 117 BAO patients, 91 patients (78%) underwent MT. In 70 patients (77%), successful recanalization could be achieved (mTICI 2b/3). In multivariable logistic regression analysis, only a higher BGL (aOR 0.97, 95% CI 0.96–0.99, p = 0.03) and higher BATMAN score (aOR 1.77, 95% CI 1.11–2.82, p = 0.02) were independently associated with vessel recanalization. Application of alteplase, or time from symptom onset-imaging revealed no independent association with recanalization status. CONCLUSION: Higher BGL was significantly associated with reduced likelihood for recanalization success besides BATMAN score as a measure of collateral quality and clot burden. BGL could be tested as a modifiable parameter to increase likelihood for recanalization in BAO stroke, aiming to improve functional outcome. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00415-021-10948-1.

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