Different hotspot p53 mutants exert distinct phenotypes and predict outcome of colorectal cancer patients

The TP53 gene is mutated in approximately 60% of all colorectal cancer (CRC) cases. Over 20% of all TP53-mutated CRC tumors carry missense mutations at position R175 or R273. Here we report that CRC tumors harboring R273 mutations are more prone to progress to metastatic disease, with decreased surv...

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Detalles Bibliográficos
Autores principales: Hassin, Ori, Nataraj, Nishanth Belugali, Shreberk-Shaked, Michal, Aylon, Yael, Yaeger, Rona, Fontemaggi, Giulia, Mukherjee, Saptaparna, Maddalena, Martino, Avioz, Adi, Iancu, Ortal, Mallel, Giuseppe, Gershoni, Anat, Grosheva, Inna, Feldmesser, Ester, Ben-Dor, Shifra, Golani, Ofra, Hendel, Ayal, Blandino, Giovanni, Kelsen, David, Yarden, Yosef, Oren, Moshe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9120190/
https://www.ncbi.nlm.nih.gov/pubmed/35589715
http://dx.doi.org/10.1038/s41467-022-30481-7

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