RNA splicing is a key mediator of tumour cell plasticity and a therapeutic vulnerability in colorectal cancer

Tumour cell plasticity is a major barrier to the efficacy of targeted cancer therapies but the mechanisms that mediate it are poorly understood. Here, we identify dysregulated RNA splicing as a key driver of tumour cell dedifferentiation in colorectal cancer (CRC). We find that Apc-deficient CRC cel...

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Detalles Bibliográficos
Autores principales: Hall, Adam E., Pohl, Sebastian Öther-Gee, Cammareri, Patrizia, Aitken, Stuart, Younger, Nicholas T., Raponi, Michela, Billard, Caroline V., Carrancio, Alfonso Bolado, Bastem, Aslihan, Freile, Paz, Haward, Fiona, Adams, Ian R., Caceres, Javier F., Preyzner, Paula, von Kriegsheim, Alex, Dunlop, Malcolm G., Din, Farhat V., Myant, Kevin B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9120198/
https://www.ncbi.nlm.nih.gov/pubmed/35589755
http://dx.doi.org/10.1038/s41467-022-30489-z

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