Sialoglycan-binding patterns of bacterial AB(5) toxin B subunits correlate with host range and toxicity, indicating evolution independent of A subunits

Many pathogenic bacteria secrete AB(5) toxins that can be virulence factors. Cytotoxic A subunits are delivered to the cytosol following B subunit binding to specific host cell surface glycans. Some B subunits are not associated with A subunits, for example, YpeB of Yersinia pestis, the etiologic ag...

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Detalles Bibliográficos
Autores principales: Khan, Naazneen, Sasmal, Aniruddha, Khedri, Zahra, Secrest, Patrick, Verhagen, Andrea, Srivastava, Saurabh, Varki, Nissi, Chen, Xi, Yu, Hai, Beddoe, Travis, Paton, Adrienne W., Paton, James C., Varki, Ajit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9120245/
https://www.ncbi.nlm.nih.gov/pubmed/35398357
http://dx.doi.org/10.1016/j.jbc.2022.101900

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