Multitrait genetic association analysis identifies 50 new risk loci for gastro-oesophageal reflux, seven new loci for Barrett’s oesophagus and provides insights into clinical heterogeneity in reflux diagnosis

OBJECTIVE: Gastro-oesophageal reflux disease (GERD) has heterogeneous aetiology primarily attributable to its symptom-based definitions. GERD genome-wide association studies (GWASs) have shown strong genetic overlaps with established risk factors such as obesity and depression. We hypothesised that...

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Detalles Bibliográficos
Autores principales: Ong, Jue-Sheng, An, Jiyuan, Han, Xikun, Law, Matthew H, Nandakumar, Priyanka, Schumacher, Johannes, Gockel, Ines, Bohmer, Anne, Jankowski, Janusz, Palles, Claire, Olsen, Catherine M, Neale, Rachel E, Fitzgerald, Rebecca, Thrift, Aaron P, Vaughan, Thomas L, Buas, Matthew F, Hinds, David A, Gharahkhani, Puya, Kendall, Bradley J, MacGregor, Stuart
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Oesophagus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9120377/
https://www.ncbi.nlm.nih.gov/pubmed/34187846
http://dx.doi.org/10.1136/gutjnl-2020-323906

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