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Inflammation-Related Epigenetic Modification: The Bridge Between Immune and Metabolism in Type 2 Diabetes

T2DM, as a typical metabolic inflammatory disease, is under the joint regulation of environmental factors and genetics, combining with a variety of epigenetic changes. Apart from epigenetic changes of islet β cells and glycometabolic tissues or organs, the inflammation-related epigenetics is also th...

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Autores principales: Ding, Qiyou, Gao, Zezheng, Chen, Keyu, Zhang, Qiqi, Hu, Shiwan, Zhao, Linhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9120428/
https://www.ncbi.nlm.nih.gov/pubmed/35603204
http://dx.doi.org/10.3389/fimmu.2022.883410
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author Ding, Qiyou
Gao, Zezheng
Chen, Keyu
Zhang, Qiqi
Hu, Shiwan
Zhao, Linhua
author_facet Ding, Qiyou
Gao, Zezheng
Chen, Keyu
Zhang, Qiqi
Hu, Shiwan
Zhao, Linhua
author_sort Ding, Qiyou
collection PubMed
description T2DM, as a typical metabolic inflammatory disease, is under the joint regulation of environmental factors and genetics, combining with a variety of epigenetic changes. Apart from epigenetic changes of islet β cells and glycometabolic tissues or organs, the inflammation-related epigenetics is also the core pathomechanism leading to β-cell dysfunction and insulin resistance. In this review, we focus on the epigenetic modification of immune cells’ proliferation, recruitment, differentiation and function, providing an overview of the key genes which regulated by DNA methylation, histone modifications, and non-coding RNA in the respect of T2DM. Meanwhile, we further summarize the present situation of T2DM epigenetic research and elucidate its prospect in T2DM clinical diagnosis and treatment.
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spelling pubmed-91204282022-05-21 Inflammation-Related Epigenetic Modification: The Bridge Between Immune and Metabolism in Type 2 Diabetes Ding, Qiyou Gao, Zezheng Chen, Keyu Zhang, Qiqi Hu, Shiwan Zhao, Linhua Front Immunol Immunology T2DM, as a typical metabolic inflammatory disease, is under the joint regulation of environmental factors and genetics, combining with a variety of epigenetic changes. Apart from epigenetic changes of islet β cells and glycometabolic tissues or organs, the inflammation-related epigenetics is also the core pathomechanism leading to β-cell dysfunction and insulin resistance. In this review, we focus on the epigenetic modification of immune cells’ proliferation, recruitment, differentiation and function, providing an overview of the key genes which regulated by DNA methylation, histone modifications, and non-coding RNA in the respect of T2DM. Meanwhile, we further summarize the present situation of T2DM epigenetic research and elucidate its prospect in T2DM clinical diagnosis and treatment. Frontiers Media S.A. 2022-05-06 /pmc/articles/PMC9120428/ /pubmed/35603204 http://dx.doi.org/10.3389/fimmu.2022.883410 Text en Copyright © 2022 Ding, Gao, Chen, Zhang, Hu and Zhao https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Ding, Qiyou
Gao, Zezheng
Chen, Keyu
Zhang, Qiqi
Hu, Shiwan
Zhao, Linhua
Inflammation-Related Epigenetic Modification: The Bridge Between Immune and Metabolism in Type 2 Diabetes
title Inflammation-Related Epigenetic Modification: The Bridge Between Immune and Metabolism in Type 2 Diabetes
title_full Inflammation-Related Epigenetic Modification: The Bridge Between Immune and Metabolism in Type 2 Diabetes
title_fullStr Inflammation-Related Epigenetic Modification: The Bridge Between Immune and Metabolism in Type 2 Diabetes
title_full_unstemmed Inflammation-Related Epigenetic Modification: The Bridge Between Immune and Metabolism in Type 2 Diabetes
title_short Inflammation-Related Epigenetic Modification: The Bridge Between Immune and Metabolism in Type 2 Diabetes
title_sort inflammation-related epigenetic modification: the bridge between immune and metabolism in type 2 diabetes
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9120428/
https://www.ncbi.nlm.nih.gov/pubmed/35603204
http://dx.doi.org/10.3389/fimmu.2022.883410
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