Cargando…

Structural insights into the mechanism of pancreatic K(ATP) channel regulation by nucleotides

ATP-sensitive potassium channels (K(ATP)) are metabolic sensors that convert the intracellular ATP/ADP ratio to the excitability of cells. They are involved in many physiological processes and implicated in several human diseases. Here we present the cryo-EM structures of the pancreatic K(ATP) chann...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Mengmeng, Wu, Jing-Xiang, Ding, Dian, Chen, Lei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9120461/ https://www.ncbi.nlm.nih.gov/pubmed/35589716 http://dx.doi.org/10.1038/s41467-022-30430-4

Ejemplares similares

Ligand binding and conformational changes of SUR1 subunit in pancreatic ATP-sensitive potassium channels
por: Wu, Jing-Xiang, et al.
Publicado: (2018)

The inhibition mechanism of the SUR2A-containing K(ATP) channel by a regulatory helix
por: Ding, Dian, et al.
Publicado: (2023)

Vascular K(ATP) channel structural dynamics reveal regulatory mechanism by Mg-nucleotides
por: Sung, Min Woo, et al.
Publicado: (2021)

Nucleotide inhibition of the pancreatic ATP-sensitive K(+) channel explored with patch-clamp fluorometry
por: Usher, Samuel G, et al.
Publicado: (2020)

Mechanistic insights on K(ATP) channel regulation from cryo-EM structures
por: Driggers, Camden M., et al.
Publicado: (2022)

Activation mechanism of ATP-sensitive K(+) channels explored with real-time nucleotide binding
por: Puljung, Michael, et al.
Publicado: (2019)

Activation of the K(ATP) channel by Mg-nucleotide interaction with SUR1
por: Proks, Peter, et al.
Publicado: (2010)

The dynamic interplay of PIP(2) and ATP in the regulation of the K(ATP) channel
por: Pipatpolkai, Tanadet, et al.
Publicado: (2022)

Leptin-induced Trafficking of K(ATP) Channels: A Mechanism to Regulate Pancreatic β-cell Excitability and Insulin Secretion
por: Cochrane, Veronica, et al.
Publicado: (2019)

Structural Determinants of Pip(2) Regulation of Inward Rectifier K(ATP) Channels
por: Shyng, Show-Ling, et al.
Publicado: (2000)

Memantine has no effect on K(ATP) channels in pancreatic β cells
por: Imai, Ryota, et al.
Publicado: (2018)

Molecular action of sulphonylureas on K(ATP) channels: a real partnership between drugs and nucleotides
por: de Wet, Heidi, et al.
Publicado: (2015)

Functional Regulation of K(ATP) Channels and Mutant Insight Into Clinical Therapeutic Strategies in Cardiovascular Diseases
por: Wang, Zhicheng, et al.
Publicado: (2022)

How ATP Inhibits the Open K(ATP) Channel
por: Craig, Tim J., et al.
Publicado: (2008)

Mechanism of ATP-sensitive K Channel Inhibition by Sulfhydryl Modification
por: Trapp, Stefan, et al.
Publicado: (1998)

Gating Mechanism of K(ATP) Channels: Function Fits Form
por: Enkvetchakul, D., et al.
Publicado: (2003)

Regulation of K(ATP) Channel Activity by Diazoxide and MgADP : Distinct Functions of the Two Nucleotide Binding Folds of the Sulfonylurea Receptor
por: Shyng, S.-L., et al.
Publicado: (1997)

Open State Destabilization by Atp Occupancy Is Mechanism Speeding Burst Exit Underlying K(ATP) Channel Inhibition by Atp
por: Li, Lehong, et al.
Publicado: (2002)

Molecular Analysis of ATP-sensitive K Channel Gating and Implications for Channel Inhibition by ATP
por: Trapp, Stefan, et al.
Publicado: (1998)

Evidence for a K(ATP) Channel in Rough Endoplasmic Reticulum (rerK(ATP) Channel) of Rat Hepatocytes
por: Salari, Sajjad, et al.
Publicado: (2015)

Structural Insights into ATP-Sensitive Potassium Channel Mechanics: A Role of Intrinsically Disordered Regions
por: Walczewska-Szewc, Katarzyna, et al.
Publicado: (2023)

Mechanical Effects on K(ATP) Channel Gating in Rat Ventricular Myocytes
por: Huang, Haixia, et al.
Publicado: (2013)

Phosphoinositides Decrease Atp Sensitivity of the Cardiac Atp-Sensitive K(+) Channel: A Molecular Probe for the Mechanism of Atp-Sensitive Inhibition
por: Fan, Zheng, et al.
Publicado: (1999)

Cardiac ATP-sensitive K+ channels. Evidence for preferential regulation by glycolysis
Publicado: (1989)

BAD and K(ATP) channels regulate neuron excitability and epileptiform activity
por: Martínez-François, Juan Ramón, et al.
Publicado: (2018)

Regulation of capillary hemodynamics by K(ATP) channels in resting skeletal muscle
por: Hirai, Daniel M., et al.
Publicado: (2021)

Upregulation of an inward rectifying K(+) channel can rescue slow Ca(2+) oscillations in K(ATP) channel deficient pancreatic islets
por: Yildirim, Vehpi, et al.
Publicado: (2017)

Glyburide Regulates UCP1 Expression in Adipocytes Independent of K(ATP) Channel Blockade
por: Qiu, Yan, et al.
Publicado: (2020)

Opening of microglial K(ATP) channels inhibits rotenone-induced neuroinflammation
por: Zhou, Fang, et al.
Publicado: (2008)

Glucose Deprivation Regulates K(ATP) Channel Trafficking via AMP-Activated Protein Kinase in Pancreatic β-Cells
por: Lim, Ajin, et al.
Publicado: (2009)

New Insight into Plant Signaling: Extracellular ATP and Uncommon Nucleotides
por: Pietrowska-Borek, Małgorzata, et al.
Publicado: (2020)

Octameric Stoichiometry of the K(ATP) Channel Complex
por: Shyng, S.-L., et al.
Publicado: (1997)

Cardiovascular K(ATP) channels and advanced aging
por: Yang, Hua-Qian, et al.
Publicado: (2016)

K(ATP) Channel Mutations and Neonatal Diabetes
por: Shimomura, Kenju, et al.
Publicado: (2017)

Block of cardiac ATP-sensitive K+ channels by external divalent cations is modulated by intracellular ATP. Evidence for allosteric regulation of the channel protein
Publicado: (1993)

A universally conserved residue in the SUR1 subunit of the K(ATP) channel is essential for translating nucleotide binding at SUR1 into channel opening
por: de Wet, Heidi, et al.
Publicado: (2012)

Dose Dependent Effect of Sulfamethoxazole on Inhibiting K(ATP) Channel of Mouse Pancreatic β Cell
por: Ogata, Hiroshi, et al.
Publicado: (2023)

Mechanism of pharmacochaperoning in a mammalian K(ATP) channel revealed by cryo-EM
por: Martin, Gregory M, et al.
Publicado: (2019)

ATP-sensitive potassium channel (K(ATP )channel) expression in the normal canine pancreas and in canine insulinomas
por: Donley, Vicky R, et al.
Publicado: (2005)

Antagonistic Regulation of Native Ca(2+)- and ATP-sensitive Cation Channels in Brain Capillaries by Nucleotides and Decavanadate
por: Csanády, László, et al.
Publicado: (2004)

Cannot write session to /tmp/vufind_sessions/sess_f3n9b5ohq7ksavu2lap76bab9o