Cryo-EM structures define ubiquinone-10 binding to mitochondrial complex I and conformational transitions accompanying Q-site occupancy

Mitochondrial complex I is a central metabolic enzyme that uses the reducing potential of NADH to reduce ubiquinone-10 (Q(10)) and drive four protons across the inner mitochondrial membrane, powering oxidative phosphorylation. Although many complex I structures are now available, the mechanisms of Q...

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Detalles Bibliográficos
Autores principales: Chung, Injae, Wright, John J., Bridges, Hannah R., Ivanov, Bozhidar S., Biner, Olivier, Pereira, Caroline S., Arantes, Guilherme M., Hirst, Judy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9120487/
https://www.ncbi.nlm.nih.gov/pubmed/35589726
http://dx.doi.org/10.1038/s41467-022-30506-1

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