Lipid droplet degradation by autophagy connects mitochondria metabolism to Prox1-driven expression of lymphatic genes and lymphangiogenesis

Autophagy has vasculoprotective roles, but whether and how it regulates lymphatic endothelial cells (LEC) homeostasis and lymphangiogenesis is unknown. Here, we show that genetic deficiency of autophagy in LEC impairs responses to VEGF-C and injury-driven corneal lymphangiogenesis. Autophagy loss in...

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Detalles Bibliográficos
Autores principales: Meçe, Odeta, Houbaert, Diede, Sassano, Maria-Livia, Durré, Tania, Maes, Hannelore, Schaaf, Marco, More, Sanket, Ganne, Maarten, García-Caballero, Melissa, Borri, Mila, Verhoeven, Jelle, Agrawal, Madhur, Jacobs, Kathryn, Bergers, Gabriele, Blacher, Silvia, Ghesquière, Bart, Dewerchin, Mieke, Swinnen, Johan V., Vinckier, Stefan, Soengas, María S., Carmeliet, Peter, Noël, Agnès, Agostinis, Patrizia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9120506/
https://www.ncbi.nlm.nih.gov/pubmed/35589749
http://dx.doi.org/10.1038/s41467-022-30490-6

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