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Cataract surgery in patients with Fuchs’ dystrophy and corneal decompensation indicated for Descemet's membrane endothelial keratoplasty
The availability of corneal donor tissue is limited in most developing countries. This study evaluated whether patients with coexisting cataract and Fuchs’ dystrophy with corneal decompensation awaiting Descemet’s membrane endothelial keratoplasty (DMEK) benefited from phacoemulsification. This is a...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9120518/ https://www.ncbi.nlm.nih.gov/pubmed/35589882 http://dx.doi.org/10.1038/s41598-022-12434-8 |
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author | Chou, Wei-Yi Kuo, Yih-Shiuan Lin, Pei-Yu |
author_facet | Chou, Wei-Yi Kuo, Yih-Shiuan Lin, Pei-Yu |
author_sort | Chou, Wei-Yi |
collection | PubMed |
description | The availability of corneal donor tissue is limited in most developing countries. This study evaluated whether patients with coexisting cataract and Fuchs’ dystrophy with corneal decompensation awaiting Descemet’s membrane endothelial keratoplasty (DMEK) benefited from phacoemulsification. This is a retrospective case–control study which included patients with Fuchs’ dystrophy and evidence of corneal decompensation awaiting DMEK. Best-corrected visual acuity (BCVA) and central corneal thickness (CCT) were documented at baseline (pre-cataract surgery in the case group, or at the time of transplantation registry in the control group), 1-month and pre-DMEK. A total of 16 phakic patients with visually significant cataracts had cataract surgery during the study period, and 15 pseudophakic patients were included as controls. There was no significant difference with regard to BCVA at baseline, 1-month or pre-DMEK between the case and control groups. Similarly, no significant difference in CCT was found at baseline, 1-month or pre-DMEK. In the case group, 4 patients with improved visual acuity post-cataract surgery chose to defer DMEK. After stratification, statistical analysis showed significantly better BCVA in the deferred group (n = 4) at 1-month post-cataract surgery, compared to the DMEK group (n = 12) (0.21 ± 0.21 vs. 0.86 ± 0.29 LogMAR, P = 0.004). The other parameters, including baseline BCVA and CCT at any time point documented, were not statistically different. In conclusion, in patients with Fuchs’ dystrophy and decompensated corneas awaiting transplantation, phacoemulsification did not lead to significant increase of corneal thickness nor deterioration of visual acuity. A few patients achieved satisfactory vision after cataract surgery and deferred endothelial keratoplasty. |
format | Online Article Text |
id | pubmed-9120518 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-91205182022-05-21 Cataract surgery in patients with Fuchs’ dystrophy and corneal decompensation indicated for Descemet's membrane endothelial keratoplasty Chou, Wei-Yi Kuo, Yih-Shiuan Lin, Pei-Yu Sci Rep Article The availability of corneal donor tissue is limited in most developing countries. This study evaluated whether patients with coexisting cataract and Fuchs’ dystrophy with corneal decompensation awaiting Descemet’s membrane endothelial keratoplasty (DMEK) benefited from phacoemulsification. This is a retrospective case–control study which included patients with Fuchs’ dystrophy and evidence of corneal decompensation awaiting DMEK. Best-corrected visual acuity (BCVA) and central corneal thickness (CCT) were documented at baseline (pre-cataract surgery in the case group, or at the time of transplantation registry in the control group), 1-month and pre-DMEK. A total of 16 phakic patients with visually significant cataracts had cataract surgery during the study period, and 15 pseudophakic patients were included as controls. There was no significant difference with regard to BCVA at baseline, 1-month or pre-DMEK between the case and control groups. Similarly, no significant difference in CCT was found at baseline, 1-month or pre-DMEK. In the case group, 4 patients with improved visual acuity post-cataract surgery chose to defer DMEK. After stratification, statistical analysis showed significantly better BCVA in the deferred group (n = 4) at 1-month post-cataract surgery, compared to the DMEK group (n = 12) (0.21 ± 0.21 vs. 0.86 ± 0.29 LogMAR, P = 0.004). The other parameters, including baseline BCVA and CCT at any time point documented, were not statistically different. In conclusion, in patients with Fuchs’ dystrophy and decompensated corneas awaiting transplantation, phacoemulsification did not lead to significant increase of corneal thickness nor deterioration of visual acuity. A few patients achieved satisfactory vision after cataract surgery and deferred endothelial keratoplasty. Nature Publishing Group UK 2022-05-19 /pmc/articles/PMC9120518/ /pubmed/35589882 http://dx.doi.org/10.1038/s41598-022-12434-8 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Chou, Wei-Yi Kuo, Yih-Shiuan Lin, Pei-Yu Cataract surgery in patients with Fuchs’ dystrophy and corneal decompensation indicated for Descemet's membrane endothelial keratoplasty |
title | Cataract surgery in patients with Fuchs’ dystrophy and corneal decompensation indicated for Descemet's membrane endothelial keratoplasty |
title_full | Cataract surgery in patients with Fuchs’ dystrophy and corneal decompensation indicated for Descemet's membrane endothelial keratoplasty |
title_fullStr | Cataract surgery in patients with Fuchs’ dystrophy and corneal decompensation indicated for Descemet's membrane endothelial keratoplasty |
title_full_unstemmed | Cataract surgery in patients with Fuchs’ dystrophy and corneal decompensation indicated for Descemet's membrane endothelial keratoplasty |
title_short | Cataract surgery in patients with Fuchs’ dystrophy and corneal decompensation indicated for Descemet's membrane endothelial keratoplasty |
title_sort | cataract surgery in patients with fuchs’ dystrophy and corneal decompensation indicated for descemet's membrane endothelial keratoplasty |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9120518/ https://www.ncbi.nlm.nih.gov/pubmed/35589882 http://dx.doi.org/10.1038/s41598-022-12434-8 |
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