Cargando…

Vaccine Side Effects Following COVID-19 Vaccination Among the Residents of the UAE—An Observational Study

COVID-19 vaccines have proven to be very safe in the clinical trials, however, there is less evidence comparing the safety of these vaccines in real-world settings. Therefore, we aim to investigate the nature and severity of the adverse effects reported and the differences based on the type of vacci...

Descripción completa

Detalles Bibliográficos
Autores principales: Ganesan, Subhashini, Al Ketbi, Latifa Mohammad Baynouna, Al Kaabi, Nawal, Al Mansoori, Mohammed, Al Maskari, Noura Nasser, Al Shamsi, Mariam Saif, Alderei, Aysha Saeed, El Eissaee, Hamada Nasser, Al Ketbi, Rudina Mubarak, Al Shamsi, Noura Saeed, Saleh, Khuloud Mohammed, Al Blooshi, Aysha Fahad, Cantarutti, Flavia Martinez, Warren, Katherine, Ahamed, Faheem, Zaher, Walid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9120526/
https://www.ncbi.nlm.nih.gov/pubmed/35602146
http://dx.doi.org/10.3389/fpubh.2022.876336
_version_ 1784710945603321856
author Ganesan, Subhashini
Al Ketbi, Latifa Mohammad Baynouna
Al Kaabi, Nawal
Al Mansoori, Mohammed
Al Maskari, Noura Nasser
Al Shamsi, Mariam Saif
Alderei, Aysha Saeed
El Eissaee, Hamada Nasser
Al Ketbi, Rudina Mubarak
Al Shamsi, Noura Saeed
Saleh, Khuloud Mohammed
Al Blooshi, Aysha Fahad
Cantarutti, Flavia Martinez
Warren, Katherine
Ahamed, Faheem
Zaher, Walid
author_facet Ganesan, Subhashini
Al Ketbi, Latifa Mohammad Baynouna
Al Kaabi, Nawal
Al Mansoori, Mohammed
Al Maskari, Noura Nasser
Al Shamsi, Mariam Saif
Alderei, Aysha Saeed
El Eissaee, Hamada Nasser
Al Ketbi, Rudina Mubarak
Al Shamsi, Noura Saeed
Saleh, Khuloud Mohammed
Al Blooshi, Aysha Fahad
Cantarutti, Flavia Martinez
Warren, Katherine
Ahamed, Faheem
Zaher, Walid
author_sort Ganesan, Subhashini
collection PubMed
description COVID-19 vaccines have proven to be very safe in the clinical trials, however, there is less evidence comparing the safety of these vaccines in real-world settings. Therefore, we aim to investigate the nature and severity of the adverse effects reported and the differences based on the type of vaccine received. A survey was conducted among 1,878 adult (≥18 years) COVID-19 vaccine recipients through online survey platforms and telephonic interviews during March to September 2021. The factors potentially associated with the reported side effects like age, gender, ethnicity, comorbidities, and previous COVID-19 infection were analyzed based on the type of vaccine received. Differences in adverse events and the severity were compared between inactivated and mRNA vaccine recipients. The major adverse effects reported by the COVID-19 vaccine recipients were pain at the site of injection, fatigue and drowsiness, and headache followed by joint/muscle pain. The adverse effects were more common among recipients of mRNA Pfizer-BioNTech vaccine than among recipients of inactive Sinopharm vaccine with the odds ratio of 1.39 (95% CI 1.14–1.68). The average number of adverse effects reported between individuals who had received Sinopharm and Pfizer-BioNTech vaccines was 1.61 ± 2.08 and 2.20 ± 2.58, respectively, and the difference was statistically significant (p <0.001). Severe adverse effects after COVID-19 vaccinations were rare and 95% of the adverse effects reported after either an inactivated or mRNA vaccine were mild requiring no or home-based treatment. The study found that individuals less than 55 years of age, female gender, with history of one or more comorbid conditions, who had received mRNA Pfizer- BioNTech vaccine, and with history of COVID-19 infections are at higher odds of developing an adverse effect post COVID-19 vaccination compared to the others.
format Online
Article
Text
id pubmed-9120526
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-91205262022-05-21 Vaccine Side Effects Following COVID-19 Vaccination Among the Residents of the UAE—An Observational Study Ganesan, Subhashini Al Ketbi, Latifa Mohammad Baynouna Al Kaabi, Nawal Al Mansoori, Mohammed Al Maskari, Noura Nasser Al Shamsi, Mariam Saif Alderei, Aysha Saeed El Eissaee, Hamada Nasser Al Ketbi, Rudina Mubarak Al Shamsi, Noura Saeed Saleh, Khuloud Mohammed Al Blooshi, Aysha Fahad Cantarutti, Flavia Martinez Warren, Katherine Ahamed, Faheem Zaher, Walid Front Public Health Public Health COVID-19 vaccines have proven to be very safe in the clinical trials, however, there is less evidence comparing the safety of these vaccines in real-world settings. Therefore, we aim to investigate the nature and severity of the adverse effects reported and the differences based on the type of vaccine received. A survey was conducted among 1,878 adult (≥18 years) COVID-19 vaccine recipients through online survey platforms and telephonic interviews during March to September 2021. The factors potentially associated with the reported side effects like age, gender, ethnicity, comorbidities, and previous COVID-19 infection were analyzed based on the type of vaccine received. Differences in adverse events and the severity were compared between inactivated and mRNA vaccine recipients. The major adverse effects reported by the COVID-19 vaccine recipients were pain at the site of injection, fatigue and drowsiness, and headache followed by joint/muscle pain. The adverse effects were more common among recipients of mRNA Pfizer-BioNTech vaccine than among recipients of inactive Sinopharm vaccine with the odds ratio of 1.39 (95% CI 1.14–1.68). The average number of adverse effects reported between individuals who had received Sinopharm and Pfizer-BioNTech vaccines was 1.61 ± 2.08 and 2.20 ± 2.58, respectively, and the difference was statistically significant (p <0.001). Severe adverse effects after COVID-19 vaccinations were rare and 95% of the adverse effects reported after either an inactivated or mRNA vaccine were mild requiring no or home-based treatment. The study found that individuals less than 55 years of age, female gender, with history of one or more comorbid conditions, who had received mRNA Pfizer- BioNTech vaccine, and with history of COVID-19 infections are at higher odds of developing an adverse effect post COVID-19 vaccination compared to the others. Frontiers Media S.A. 2022-05-06 /pmc/articles/PMC9120526/ /pubmed/35602146 http://dx.doi.org/10.3389/fpubh.2022.876336 Text en Copyright © 2022 Ganesan, Al Ketbi, Al Kaabi, Al Mansoori, Al Maskari, Al Shamsi, Alderei, El Eissaee, Al Ketbi, Al Shamsi, Saleh, Al Blooshi, Cantarutti, Warren, Ahamed and Zaher. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Public Health
Ganesan, Subhashini
Al Ketbi, Latifa Mohammad Baynouna
Al Kaabi, Nawal
Al Mansoori, Mohammed
Al Maskari, Noura Nasser
Al Shamsi, Mariam Saif
Alderei, Aysha Saeed
El Eissaee, Hamada Nasser
Al Ketbi, Rudina Mubarak
Al Shamsi, Noura Saeed
Saleh, Khuloud Mohammed
Al Blooshi, Aysha Fahad
Cantarutti, Flavia Martinez
Warren, Katherine
Ahamed, Faheem
Zaher, Walid
Vaccine Side Effects Following COVID-19 Vaccination Among the Residents of the UAE—An Observational Study
title Vaccine Side Effects Following COVID-19 Vaccination Among the Residents of the UAE—An Observational Study
title_full Vaccine Side Effects Following COVID-19 Vaccination Among the Residents of the UAE—An Observational Study
title_fullStr Vaccine Side Effects Following COVID-19 Vaccination Among the Residents of the UAE—An Observational Study
title_full_unstemmed Vaccine Side Effects Following COVID-19 Vaccination Among the Residents of the UAE—An Observational Study
title_short Vaccine Side Effects Following COVID-19 Vaccination Among the Residents of the UAE—An Observational Study
title_sort vaccine side effects following covid-19 vaccination among the residents of the uae—an observational study
topic Public Health
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9120526/
https://www.ncbi.nlm.nih.gov/pubmed/35602146
http://dx.doi.org/10.3389/fpubh.2022.876336
work_keys_str_mv AT ganesansubhashini vaccinesideeffectsfollowingcovid19vaccinationamongtheresidentsoftheuaeanobservationalstudy
AT alketbilatifamohammadbaynouna vaccinesideeffectsfollowingcovid19vaccinationamongtheresidentsoftheuaeanobservationalstudy
AT alkaabinawal vaccinesideeffectsfollowingcovid19vaccinationamongtheresidentsoftheuaeanobservationalstudy
AT almansoorimohammed vaccinesideeffectsfollowingcovid19vaccinationamongtheresidentsoftheuaeanobservationalstudy
AT almaskarinouranasser vaccinesideeffectsfollowingcovid19vaccinationamongtheresidentsoftheuaeanobservationalstudy
AT alshamsimariamsaif vaccinesideeffectsfollowingcovid19vaccinationamongtheresidentsoftheuaeanobservationalstudy
AT aldereiayshasaeed vaccinesideeffectsfollowingcovid19vaccinationamongtheresidentsoftheuaeanobservationalstudy
AT eleissaeehamadanasser vaccinesideeffectsfollowingcovid19vaccinationamongtheresidentsoftheuaeanobservationalstudy
AT alketbirudinamubarak vaccinesideeffectsfollowingcovid19vaccinationamongtheresidentsoftheuaeanobservationalstudy
AT alshamsinourasaeed vaccinesideeffectsfollowingcovid19vaccinationamongtheresidentsoftheuaeanobservationalstudy
AT salehkhuloudmohammed vaccinesideeffectsfollowingcovid19vaccinationamongtheresidentsoftheuaeanobservationalstudy
AT alblooshiayshafahad vaccinesideeffectsfollowingcovid19vaccinationamongtheresidentsoftheuaeanobservationalstudy
AT cantaruttiflaviamartinez vaccinesideeffectsfollowingcovid19vaccinationamongtheresidentsoftheuaeanobservationalstudy
AT warrenkatherine vaccinesideeffectsfollowingcovid19vaccinationamongtheresidentsoftheuaeanobservationalstudy
AT ahamedfaheem vaccinesideeffectsfollowingcovid19vaccinationamongtheresidentsoftheuaeanobservationalstudy
AT zaherwalid vaccinesideeffectsfollowingcovid19vaccinationamongtheresidentsoftheuaeanobservationalstudy