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Periodontitis in First Degree-Relatives of Individuals With Rheumatoid Arthritis: A Short Narrative Review

Periodontal disease (PD) and rheumatoid arthritis (RA) are chronic inflammatory diseases with a bi-directional relationship. Both share common genetic and environmental risk factors and result in the progressive destruction of bone and connective tissue. First degree relatives of patients with RA (F...

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Autores principales: Zekeridou, Alkisti, Gilbert, Benoit, Finckh, Axel, Giannopoulou, Catherine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9120603/
https://www.ncbi.nlm.nih.gov/pubmed/35601818
http://dx.doi.org/10.3389/froh.2022.895753
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author Zekeridou, Alkisti
Gilbert, Benoit
Finckh, Axel
Giannopoulou, Catherine
author_facet Zekeridou, Alkisti
Gilbert, Benoit
Finckh, Axel
Giannopoulou, Catherine
author_sort Zekeridou, Alkisti
collection PubMed
description Periodontal disease (PD) and rheumatoid arthritis (RA) are chronic inflammatory diseases with a bi-directional relationship. Both share common genetic and environmental risk factors and result in the progressive destruction of bone and connective tissue. First degree relatives of patients with RA (FDR-RA) are one of the at-risk populations for RA. The etiopathogenic mechanisms of their susceptibility are currently being explored, focusing mostly on the role of anti–cyclic citrullinated protein/ peptide antibodies (ACPA) in triggering RA. Oral microbiota and their relation with oral health has been suggested as a factor influencing the risk of the FDR-RA developing RA. In particular, compromised periodontal status often correlates with ACPA seropositivity in FDR-RA. The presence of periodontal pathogens such as Porphyromonas gingivalis, in oral microbiota has been proposed to increase the risk of developing RA through its uniquely expressed peptidyl arginine deiminase (PPAD), capable of citrullinating both host and bacterial peptides. Aggregatibacter actinomycetemcomitans and its leukotoxin A (LtxA), also induces hypercitrullination in host neutrophils. Common risk factors of periodontitis and RA such as genetic predisposition, smoking, higher local and systemic inflammatory burden, are discussed in the literature. Based on those mechanisms periodontal disease seems to be presented as one of the factors triggering RA in FDR-RA. Larger studies evaluating all the potential mechanisms linking RA and periodontitis are needed in FDR-RA to confirm that periodontal disease should be considered in the screening of FDR-RA.
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spelling pubmed-91206032022-05-21 Periodontitis in First Degree-Relatives of Individuals With Rheumatoid Arthritis: A Short Narrative Review Zekeridou, Alkisti Gilbert, Benoit Finckh, Axel Giannopoulou, Catherine Front Oral Health Oral Health Periodontal disease (PD) and rheumatoid arthritis (RA) are chronic inflammatory diseases with a bi-directional relationship. Both share common genetic and environmental risk factors and result in the progressive destruction of bone and connective tissue. First degree relatives of patients with RA (FDR-RA) are one of the at-risk populations for RA. The etiopathogenic mechanisms of their susceptibility are currently being explored, focusing mostly on the role of anti–cyclic citrullinated protein/ peptide antibodies (ACPA) in triggering RA. Oral microbiota and their relation with oral health has been suggested as a factor influencing the risk of the FDR-RA developing RA. In particular, compromised periodontal status often correlates with ACPA seropositivity in FDR-RA. The presence of periodontal pathogens such as Porphyromonas gingivalis, in oral microbiota has been proposed to increase the risk of developing RA through its uniquely expressed peptidyl arginine deiminase (PPAD), capable of citrullinating both host and bacterial peptides. Aggregatibacter actinomycetemcomitans and its leukotoxin A (LtxA), also induces hypercitrullination in host neutrophils. Common risk factors of periodontitis and RA such as genetic predisposition, smoking, higher local and systemic inflammatory burden, are discussed in the literature. Based on those mechanisms periodontal disease seems to be presented as one of the factors triggering RA in FDR-RA. Larger studies evaluating all the potential mechanisms linking RA and periodontitis are needed in FDR-RA to confirm that periodontal disease should be considered in the screening of FDR-RA. Frontiers Media S.A. 2022-05-06 /pmc/articles/PMC9120603/ /pubmed/35601818 http://dx.doi.org/10.3389/froh.2022.895753 Text en Copyright © 2022 Zekeridou, Gilbert, Finckh and Giannopoulou. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oral Health
Zekeridou, Alkisti
Gilbert, Benoit
Finckh, Axel
Giannopoulou, Catherine
Periodontitis in First Degree-Relatives of Individuals With Rheumatoid Arthritis: A Short Narrative Review
title Periodontitis in First Degree-Relatives of Individuals With Rheumatoid Arthritis: A Short Narrative Review
title_full Periodontitis in First Degree-Relatives of Individuals With Rheumatoid Arthritis: A Short Narrative Review
title_fullStr Periodontitis in First Degree-Relatives of Individuals With Rheumatoid Arthritis: A Short Narrative Review
title_full_unstemmed Periodontitis in First Degree-Relatives of Individuals With Rheumatoid Arthritis: A Short Narrative Review
title_short Periodontitis in First Degree-Relatives of Individuals With Rheumatoid Arthritis: A Short Narrative Review
title_sort periodontitis in first degree-relatives of individuals with rheumatoid arthritis: a short narrative review
topic Oral Health
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9120603/
https://www.ncbi.nlm.nih.gov/pubmed/35601818
http://dx.doi.org/10.3389/froh.2022.895753
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