The Role and Function of Mucins and Its Relationship to Inflammatory Bowel Disease

Mucus is present throughout the gastrointestinal tract and is essential for regulating gut microbiota homeostasis and preventing disease by protecting the gastrointestinal barrier from microorganisms, pathogens and toxins or other irritants. Mucin (MUC)-2 is a secreted protein produced by epithelial...

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Autores principales: Kang, Youra, Park, Hyeonjeong, Choe, Byung-Ho, Kang, Ben
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9120656/
https://www.ncbi.nlm.nih.gov/pubmed/35602503
http://dx.doi.org/10.3389/fmed.2022.848344
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author Kang, Youra
Park, Hyeonjeong
Choe, Byung-Ho
Kang, Ben
author_facet Kang, Youra
Park, Hyeonjeong
Choe, Byung-Ho
Kang, Ben
author_sort Kang, Youra
collection PubMed
description Mucus is present throughout the gastrointestinal tract and is essential for regulating gut microbiota homeostasis and preventing disease by protecting the gastrointestinal barrier from microorganisms, pathogens and toxins or other irritants. Mucin (MUC)-2 is a secreted protein produced by epithelial goblet cells as the main component of mucus. Defects in the gastrointestinal tract, such as inflammation and ulcers, cause damage to the mucus barrier, which can worsen mucus quality and reduce mucus production. Therefore, we would like to review the characteristics of MUC2 and its role in intestinal disorders and highlight the importance of further studies. We also investigated whether the role of MUC2 differs between children and adults, ulcerative colitis (UC) and Crohn's disease (CD).
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spelling pubmed-91206562022-05-21 The Role and Function of Mucins and Its Relationship to Inflammatory Bowel Disease Kang, Youra Park, Hyeonjeong Choe, Byung-Ho Kang, Ben Front Med (Lausanne) Medicine Mucus is present throughout the gastrointestinal tract and is essential for regulating gut microbiota homeostasis and preventing disease by protecting the gastrointestinal barrier from microorganisms, pathogens and toxins or other irritants. Mucin (MUC)-2 is a secreted protein produced by epithelial goblet cells as the main component of mucus. Defects in the gastrointestinal tract, such as inflammation and ulcers, cause damage to the mucus barrier, which can worsen mucus quality and reduce mucus production. Therefore, we would like to review the characteristics of MUC2 and its role in intestinal disorders and highlight the importance of further studies. We also investigated whether the role of MUC2 differs between children and adults, ulcerative colitis (UC) and Crohn's disease (CD). Frontiers Media S.A. 2022-05-06 /pmc/articles/PMC9120656/ /pubmed/35602503 http://dx.doi.org/10.3389/fmed.2022.848344 Text en Copyright © 2022 Kang, Park, Choe and Kang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Kang, Youra
Park, Hyeonjeong
Choe, Byung-Ho
Kang, Ben
The Role and Function of Mucins and Its Relationship to Inflammatory Bowel Disease
title The Role and Function of Mucins and Its Relationship to Inflammatory Bowel Disease
title_full The Role and Function of Mucins and Its Relationship to Inflammatory Bowel Disease
title_fullStr The Role and Function of Mucins and Its Relationship to Inflammatory Bowel Disease
title_full_unstemmed The Role and Function of Mucins and Its Relationship to Inflammatory Bowel Disease
title_short The Role and Function of Mucins and Its Relationship to Inflammatory Bowel Disease
title_sort role and function of mucins and its relationship to inflammatory bowel disease
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9120656/
https://www.ncbi.nlm.nih.gov/pubmed/35602503
http://dx.doi.org/10.3389/fmed.2022.848344
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