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Alterations in resting‐state whole‐brain functional connectivity pattern similarity in bipolar disorder patients

BACKGROUND: Previous neuroimaging studies have extensively demonstrated many signs of functionally spontaneous local neural activity abnormalities in bipolar disorder (BD) patients using resting‐state functional magnetic resonance imaging (rs‐fMRI). However, how to identify the changes of voxel‐wise...

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Autores principales: Ping, Liangliang, Zhou, Cong, Sun, Shan, Wang, Wenqiang, Zheng, Qi, You, Zhiyi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9120726/
https://www.ncbi.nlm.nih.gov/pubmed/35451228
http://dx.doi.org/10.1002/brb3.2580
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author Ping, Liangliang
Zhou, Cong
Sun, Shan
Wang, Wenqiang
Zheng, Qi
You, Zhiyi
author_facet Ping, Liangliang
Zhou, Cong
Sun, Shan
Wang, Wenqiang
Zheng, Qi
You, Zhiyi
author_sort Ping, Liangliang
collection PubMed
description BACKGROUND: Previous neuroimaging studies have extensively demonstrated many signs of functionally spontaneous local neural activity abnormalities in bipolar disorder (BD) patients using resting‐state functional magnetic resonance imaging (rs‐fMRI). However, how to identify the changes of voxel‐wise whole‐brain functional connectivity pattern and its corresponding functional connectivity changes remain largely unclear in BD patients. The current study aimed to investigate the voxel‐wise changes of functional connectivity patterns in BD patients using publicly available data from the UCLA CNP LA5c Study. METHODS: A total of 45 BD patients and 115 healthy control subjects were finally included and whole‐brain functional connectivity homogeneity (FcHo) was calculated from their rs‐fMRI. Moreover, the alterations of corresponding functional connectivity were subsequently identified using seed‐based resting‐state functional connectivity analysis. RESULTS: Individuals with BD exhibited significantly lower FcHo values in the left middle temporal gyrus (MTG) when compared with controls. Functional connectivity findings further indicated decreased functional connectivities between left MTG and cluster 1 (left superior temporal gyrus, extend to middle temporal gyrus, rolandic operculum), cluster 2 (right postcentral, extend to right precentral) in BD patients. The mean FcHo values of left MTG were positively correlated with insomnia, middle scores and appetite increase scores. The mean functional connectivities of left MTG to cluster 1 were negatively correlated with grandiose delusions scores. While the functional connections between left MTG with cluster 2 were negatively correlated with delusions of reference and positively correlated with insomnia, middle scores in BD patients. CONCLUSIONS: Our findings suggested that abnormal FcHo and functional connections in those areas of the brain involving DMN and SMN networks might play a crucial role in the neuropathology of BD.
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spelling pubmed-91207262022-05-21 Alterations in resting‐state whole‐brain functional connectivity pattern similarity in bipolar disorder patients Ping, Liangliang Zhou, Cong Sun, Shan Wang, Wenqiang Zheng, Qi You, Zhiyi Brain Behav Original Articles BACKGROUND: Previous neuroimaging studies have extensively demonstrated many signs of functionally spontaneous local neural activity abnormalities in bipolar disorder (BD) patients using resting‐state functional magnetic resonance imaging (rs‐fMRI). However, how to identify the changes of voxel‐wise whole‐brain functional connectivity pattern and its corresponding functional connectivity changes remain largely unclear in BD patients. The current study aimed to investigate the voxel‐wise changes of functional connectivity patterns in BD patients using publicly available data from the UCLA CNP LA5c Study. METHODS: A total of 45 BD patients and 115 healthy control subjects were finally included and whole‐brain functional connectivity homogeneity (FcHo) was calculated from their rs‐fMRI. Moreover, the alterations of corresponding functional connectivity were subsequently identified using seed‐based resting‐state functional connectivity analysis. RESULTS: Individuals with BD exhibited significantly lower FcHo values in the left middle temporal gyrus (MTG) when compared with controls. Functional connectivity findings further indicated decreased functional connectivities between left MTG and cluster 1 (left superior temporal gyrus, extend to middle temporal gyrus, rolandic operculum), cluster 2 (right postcentral, extend to right precentral) in BD patients. The mean FcHo values of left MTG were positively correlated with insomnia, middle scores and appetite increase scores. The mean functional connectivities of left MTG to cluster 1 were negatively correlated with grandiose delusions scores. While the functional connections between left MTG with cluster 2 were negatively correlated with delusions of reference and positively correlated with insomnia, middle scores in BD patients. CONCLUSIONS: Our findings suggested that abnormal FcHo and functional connections in those areas of the brain involving DMN and SMN networks might play a crucial role in the neuropathology of BD. John Wiley and Sons Inc. 2022-04-21 /pmc/articles/PMC9120726/ /pubmed/35451228 http://dx.doi.org/10.1002/brb3.2580 Text en © 2022 The Authors. Brain and Behavior published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Ping, Liangliang
Zhou, Cong
Sun, Shan
Wang, Wenqiang
Zheng, Qi
You, Zhiyi
Alterations in resting‐state whole‐brain functional connectivity pattern similarity in bipolar disorder patients
title Alterations in resting‐state whole‐brain functional connectivity pattern similarity in bipolar disorder patients
title_full Alterations in resting‐state whole‐brain functional connectivity pattern similarity in bipolar disorder patients
title_fullStr Alterations in resting‐state whole‐brain functional connectivity pattern similarity in bipolar disorder patients
title_full_unstemmed Alterations in resting‐state whole‐brain functional connectivity pattern similarity in bipolar disorder patients
title_short Alterations in resting‐state whole‐brain functional connectivity pattern similarity in bipolar disorder patients
title_sort alterations in resting‐state whole‐brain functional connectivity pattern similarity in bipolar disorder patients
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9120726/
https://www.ncbi.nlm.nih.gov/pubmed/35451228
http://dx.doi.org/10.1002/brb3.2580
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