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An overview of sickle cell disease from the socio-demographic triangle - a Nigerian single-institution retrospective study

INTRODUCTION: Sickle cell disease (SCD) is a hereditary red blood cell disorder of public health importance globally with Nigeria the epicenter zone in Africa. There is a paucity of knowledge on how hemoglobin variants, personal characteristics, and environment (socio-demographic triangle) interact...

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Autores principales: Nwabuko, Ogbonna Collins, Onwuchekwa, Uwa, Iheji, Okechukwu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The African Field Epidemiology Network 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9120745/
https://www.ncbi.nlm.nih.gov/pubmed/35655681
http://dx.doi.org/10.11604/pamj.2022.41.161.27117
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author Nwabuko, Ogbonna Collins
Onwuchekwa, Uwa
Iheji, Okechukwu
author_facet Nwabuko, Ogbonna Collins
Onwuchekwa, Uwa
Iheji, Okechukwu
author_sort Nwabuko, Ogbonna Collins
collection PubMed
description INTRODUCTION: Sickle cell disease (SCD) is a hereditary red blood cell disorder of public health importance globally with Nigeria the epicenter zone in Africa. There is a paucity of knowledge on how hemoglobin variants, personal characteristics, and environment (socio-demographic triangle) interact to influence SCD propagation. A clinical overview of these epidemiologic parameters may proffer strategies for controlling the SCD disease burden. The objective of this study was to examine the prevalence patterns of SCD, including other associated epidemiologic and hematological (i.e., hemoglobin concentration, ABO blood groups) parameters from laboratory data. METHODS: this was a retrospective cross-sectional study of 138 newly diagnosed SCD patients in the laboratory unit of the department of haematology using routine alkaline cellulose acetate hemoglobin electrophoresis technique from 2013 to 2014. Demographic and other relevant data were obtained from case notes and laboratory records at the presentation. The agent-host-environment variables were used in the construction of the epidemiological triad chain of transmission. RESULTS: a total of 138 (1.63%) newly diagnosed SCD patients aged 7 months to 41 years made up of 39% (0.63% SCD prevalence) adults and 61% (1% SCD prevalence) pediatric age-groups were seen out of 8457 consecutive patients screened within the study period. About 98.55% and 1.45% were homozygous sickle-hemoglobin (SS) and heterozygous sickle-hemoglobin C (SC) variants, respectively. The pediatric department (CHER+CHOP) recorded the highest proportion of SCD (65%). In contrast, the public health department had the least proportion (1%). There was a statistically significant difference in the gender status and the months of SCD diagnosis (p=0.0147). The month of April had the highest proportion of SCD. A majority (66.7%) of the SCD had moderate grade anemia. CONCLUSION: the study revealed a gender disparity in the months of SCD diagnosis. However, there was no statistical difference in the pediatric and adult SCD prevalence patterns.
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spelling pubmed-91207452022-06-01 An overview of sickle cell disease from the socio-demographic triangle - a Nigerian single-institution retrospective study Nwabuko, Ogbonna Collins Onwuchekwa, Uwa Iheji, Okechukwu Pan Afr Med J Research INTRODUCTION: Sickle cell disease (SCD) is a hereditary red blood cell disorder of public health importance globally with Nigeria the epicenter zone in Africa. There is a paucity of knowledge on how hemoglobin variants, personal characteristics, and environment (socio-demographic triangle) interact to influence SCD propagation. A clinical overview of these epidemiologic parameters may proffer strategies for controlling the SCD disease burden. The objective of this study was to examine the prevalence patterns of SCD, including other associated epidemiologic and hematological (i.e., hemoglobin concentration, ABO blood groups) parameters from laboratory data. METHODS: this was a retrospective cross-sectional study of 138 newly diagnosed SCD patients in the laboratory unit of the department of haematology using routine alkaline cellulose acetate hemoglobin electrophoresis technique from 2013 to 2014. Demographic and other relevant data were obtained from case notes and laboratory records at the presentation. The agent-host-environment variables were used in the construction of the epidemiological triad chain of transmission. RESULTS: a total of 138 (1.63%) newly diagnosed SCD patients aged 7 months to 41 years made up of 39% (0.63% SCD prevalence) adults and 61% (1% SCD prevalence) pediatric age-groups were seen out of 8457 consecutive patients screened within the study period. About 98.55% and 1.45% were homozygous sickle-hemoglobin (SS) and heterozygous sickle-hemoglobin C (SC) variants, respectively. The pediatric department (CHER+CHOP) recorded the highest proportion of SCD (65%). In contrast, the public health department had the least proportion (1%). There was a statistically significant difference in the gender status and the months of SCD diagnosis (p=0.0147). The month of April had the highest proportion of SCD. A majority (66.7%) of the SCD had moderate grade anemia. CONCLUSION: the study revealed a gender disparity in the months of SCD diagnosis. However, there was no statistical difference in the pediatric and adult SCD prevalence patterns. The African Field Epidemiology Network 2022-02-23 /pmc/articles/PMC9120745/ /pubmed/35655681 http://dx.doi.org/10.11604/pamj.2022.41.161.27117 Text en Copyright: Ogbonna Collins Nwabuko et al. https://creativecommons.org/licenses/by/4.0/The Pan African Medical Journal (ISSN: 1937-8688). This is an Open Access article distributed under the terms of the Creative Commons Attribution International 4.0 License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Nwabuko, Ogbonna Collins
Onwuchekwa, Uwa
Iheji, Okechukwu
An overview of sickle cell disease from the socio-demographic triangle - a Nigerian single-institution retrospective study
title An overview of sickle cell disease from the socio-demographic triangle - a Nigerian single-institution retrospective study
title_full An overview of sickle cell disease from the socio-demographic triangle - a Nigerian single-institution retrospective study
title_fullStr An overview of sickle cell disease from the socio-demographic triangle - a Nigerian single-institution retrospective study
title_full_unstemmed An overview of sickle cell disease from the socio-demographic triangle - a Nigerian single-institution retrospective study
title_short An overview of sickle cell disease from the socio-demographic triangle - a Nigerian single-institution retrospective study
title_sort overview of sickle cell disease from the socio-demographic triangle - a nigerian single-institution retrospective study
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9120745/
https://www.ncbi.nlm.nih.gov/pubmed/35655681
http://dx.doi.org/10.11604/pamj.2022.41.161.27117
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