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Role of ABO Blood Group in SARS-CoV-2 Infection in Households

An association between certain ABO/Rh blood groups and susceptibility to SARS-CoV-2 infection has been proposed for adults, although this remains controversial. In children and adolescents, the relationship is unclear due to a lack of robust data. Here, we investigated the association of ABO/Rh bloo...

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Autores principales: Janda, Ales, Engel, Corinna, Remppis, Jonathan, Enkel, Sigrid, Peter, Andreas, Hörber, Sebastian, Ganzenmueller, Tina, Schober, Sarah, Weinstock, Christof, Jacobsen, Eva-Maria, Fabricius, Dorit, Zernickel, Maria, Stamminger, Thomas, Dietz, Andrea, Groß, Hans-Jürgen, Bode, Sebastian F. N., Haddad, Anneke D. M., Elling, Roland, Stich, Maximilian, Tönshoff, Burkhard, Henneke, Philipp, Debatin, Klaus-Michael, Franz, Axel R., Renk, Hanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9120758/
https://www.ncbi.nlm.nih.gov/pubmed/35602077
http://dx.doi.org/10.3389/fmicb.2022.857965
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author Janda, Ales
Engel, Corinna
Remppis, Jonathan
Enkel, Sigrid
Peter, Andreas
Hörber, Sebastian
Ganzenmueller, Tina
Schober, Sarah
Weinstock, Christof
Jacobsen, Eva-Maria
Fabricius, Dorit
Zernickel, Maria
Stamminger, Thomas
Dietz, Andrea
Groß, Hans-Jürgen
Bode, Sebastian F. N.
Haddad, Anneke D. M.
Elling, Roland
Stich, Maximilian
Tönshoff, Burkhard
Henneke, Philipp
Debatin, Klaus-Michael
Franz, Axel R.
Renk, Hanna
author_facet Janda, Ales
Engel, Corinna
Remppis, Jonathan
Enkel, Sigrid
Peter, Andreas
Hörber, Sebastian
Ganzenmueller, Tina
Schober, Sarah
Weinstock, Christof
Jacobsen, Eva-Maria
Fabricius, Dorit
Zernickel, Maria
Stamminger, Thomas
Dietz, Andrea
Groß, Hans-Jürgen
Bode, Sebastian F. N.
Haddad, Anneke D. M.
Elling, Roland
Stich, Maximilian
Tönshoff, Burkhard
Henneke, Philipp
Debatin, Klaus-Michael
Franz, Axel R.
Renk, Hanna
author_sort Janda, Ales
collection PubMed
description An association between certain ABO/Rh blood groups and susceptibility to SARS-CoV-2 infection has been proposed for adults, although this remains controversial. In children and adolescents, the relationship is unclear due to a lack of robust data. Here, we investigated the association of ABO/Rh blood groups and SARS-CoV-2 in a multi-center study comprising 163 households with 281 children and 355 adults and at least one SARS-CoV-2 seropositive individual as determined by three independent assays as a proxy for previous infection. In line with previous findings, we found a higher frequency of blood group A (+ 6%) and a lower frequency of blood group O (−6%) among the SARS-CoV-2 seropositive adults compared to the seronegative ones. This trend was not seen in children. In contrast, SARS-CoV-2 seropositive children had a significantly lower frequency of Rh-positive blood groups. ABO compatibility did not seem to play a role in SARS-CoV-2 transmission within the families. A correction for family clusters was performed and estimated fixed effects of the blood group on the risk of SARS-CoV-2 seropositivity and symptomatic infection were determined. Although we found a different distribution of blood groups in seropositive individuals compared to the reference population, the risk of SARS-CoV-2 seropositivity or symptomatic infection was not increased in children or in adults with blood group A or AB versus O or B. Increasing age was the only parameter positively correlating with the risk of SARS-CoV-2 infection. In conclusion, specific ABO/Rh blood groups and ABO compatibility appear not to predispose for SARS-CoV-2 susceptibility in children.
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spelling pubmed-91207582022-05-21 Role of ABO Blood Group in SARS-CoV-2 Infection in Households Janda, Ales Engel, Corinna Remppis, Jonathan Enkel, Sigrid Peter, Andreas Hörber, Sebastian Ganzenmueller, Tina Schober, Sarah Weinstock, Christof Jacobsen, Eva-Maria Fabricius, Dorit Zernickel, Maria Stamminger, Thomas Dietz, Andrea Groß, Hans-Jürgen Bode, Sebastian F. N. Haddad, Anneke D. M. Elling, Roland Stich, Maximilian Tönshoff, Burkhard Henneke, Philipp Debatin, Klaus-Michael Franz, Axel R. Renk, Hanna Front Microbiol Microbiology An association between certain ABO/Rh blood groups and susceptibility to SARS-CoV-2 infection has been proposed for adults, although this remains controversial. In children and adolescents, the relationship is unclear due to a lack of robust data. Here, we investigated the association of ABO/Rh blood groups and SARS-CoV-2 in a multi-center study comprising 163 households with 281 children and 355 adults and at least one SARS-CoV-2 seropositive individual as determined by three independent assays as a proxy for previous infection. In line with previous findings, we found a higher frequency of blood group A (+ 6%) and a lower frequency of blood group O (−6%) among the SARS-CoV-2 seropositive adults compared to the seronegative ones. This trend was not seen in children. In contrast, SARS-CoV-2 seropositive children had a significantly lower frequency of Rh-positive blood groups. ABO compatibility did not seem to play a role in SARS-CoV-2 transmission within the families. A correction for family clusters was performed and estimated fixed effects of the blood group on the risk of SARS-CoV-2 seropositivity and symptomatic infection were determined. Although we found a different distribution of blood groups in seropositive individuals compared to the reference population, the risk of SARS-CoV-2 seropositivity or symptomatic infection was not increased in children or in adults with blood group A or AB versus O or B. Increasing age was the only parameter positively correlating with the risk of SARS-CoV-2 infection. In conclusion, specific ABO/Rh blood groups and ABO compatibility appear not to predispose for SARS-CoV-2 susceptibility in children. Frontiers Media S.A. 2022-05-06 /pmc/articles/PMC9120758/ /pubmed/35602077 http://dx.doi.org/10.3389/fmicb.2022.857965 Text en Copyright © 2022 Janda, Engel, Remppis, Enkel, Peter, Hörber, Ganzenmueller, Schober, Weinstock, Jacobsen, Fabricius, Zernickel, Stamminger, Dietz, Groß, Bode, Haddad, Elling, Stich, Tönshoff, Henneke, Debatin, Franz and Renk. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Janda, Ales
Engel, Corinna
Remppis, Jonathan
Enkel, Sigrid
Peter, Andreas
Hörber, Sebastian
Ganzenmueller, Tina
Schober, Sarah
Weinstock, Christof
Jacobsen, Eva-Maria
Fabricius, Dorit
Zernickel, Maria
Stamminger, Thomas
Dietz, Andrea
Groß, Hans-Jürgen
Bode, Sebastian F. N.
Haddad, Anneke D. M.
Elling, Roland
Stich, Maximilian
Tönshoff, Burkhard
Henneke, Philipp
Debatin, Klaus-Michael
Franz, Axel R.
Renk, Hanna
Role of ABO Blood Group in SARS-CoV-2 Infection in Households
title Role of ABO Blood Group in SARS-CoV-2 Infection in Households
title_full Role of ABO Blood Group in SARS-CoV-2 Infection in Households
title_fullStr Role of ABO Blood Group in SARS-CoV-2 Infection in Households
title_full_unstemmed Role of ABO Blood Group in SARS-CoV-2 Infection in Households
title_short Role of ABO Blood Group in SARS-CoV-2 Infection in Households
title_sort role of abo blood group in sars-cov-2 infection in households
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9120758/
https://www.ncbi.nlm.nih.gov/pubmed/35602077
http://dx.doi.org/10.3389/fmicb.2022.857965
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