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Dietary Acid Load and Bone Health: A Systematic Review and Meta-Analysis of Observational Studies

Findings on the association between dietary acid load (DAL) and bone health are conflicting. This study aimed to summarize available studies on the association between DAL and risk of fractures or bone mineral density (BMD) in adults. Online databases including PubMed, Scopus, and Embase were search...

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Autores principales: Gholami, Fatemeh, Naghshi, Sina, Samadi, Mahsa, Rasaei, Niloufar, Mirzaei, Khadijeh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9120865/
https://www.ncbi.nlm.nih.gov/pubmed/35600825
http://dx.doi.org/10.3389/fnut.2022.869132
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author Gholami, Fatemeh
Naghshi, Sina
Samadi, Mahsa
Rasaei, Niloufar
Mirzaei, Khadijeh
author_facet Gholami, Fatemeh
Naghshi, Sina
Samadi, Mahsa
Rasaei, Niloufar
Mirzaei, Khadijeh
author_sort Gholami, Fatemeh
collection PubMed
description Findings on the association between dietary acid load (DAL) and bone health are conflicting. This study aimed to summarize available studies on the association between DAL and risk of fractures or bone mineral density (BMD) in adults. Online databases including PubMed, Scopus, and Embase were searched for relevant studies published up to June 2021, using pertinent keywords. We identified observational studies (cohort, case-control, and cross-sectional) investigating the association between DAL and risk of fractures or BMD, then selected studies following these reported criteria: RRs with corresponding 95% CIs for the relationship between DAL and fracture risk; correlation coefficients for the association between DAL and BMD; and mean ± SD of BMD values across the categories of DAL. Overall, 17 studies with 80545 individuals were included. There was no significant relationship between the PRAL and fracture risk (Pooled RR: 1.18; 95% confidence interval 0.98 to 1.41, I(2) = 60.6%). Moreover, a similar association was observed between the NEAP and fracture risk (Pooled RR: 1.41, 95% CI: 0.79 to 2.52, I(2) = 54.1%). The results of five studies from four publications revealed no significant association between dietary PRAL score and femoral and spinal BMD (WMD femoral = −0.01, 95% confidence interval: −0.02 to 0.01, I(2) = 76.5%; WMD spinal = −0.01, 95% CI: −0.03 to 0.01, I(2) = 56.7%). However, being in the highest category of NEAP was significantly associated with a lower femoral and spinal BMD (WMD femoral = −0.01, 95% CI: −0.02 to −0.00, I(2) = 82.1%; WMD spinal = −0.02, 95% CI: −0.03 to −0.01, I(2) = 93%). It was showed that adopting diets high in acidity was not associated with risk of fractures. We also found a significant negative relationship between NEAP and BMD. However, DAL based on PRAL was not associated with BMD.
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spelling pubmed-91208652022-05-21 Dietary Acid Load and Bone Health: A Systematic Review and Meta-Analysis of Observational Studies Gholami, Fatemeh Naghshi, Sina Samadi, Mahsa Rasaei, Niloufar Mirzaei, Khadijeh Front Nutr Nutrition Findings on the association between dietary acid load (DAL) and bone health are conflicting. This study aimed to summarize available studies on the association between DAL and risk of fractures or bone mineral density (BMD) in adults. Online databases including PubMed, Scopus, and Embase were searched for relevant studies published up to June 2021, using pertinent keywords. We identified observational studies (cohort, case-control, and cross-sectional) investigating the association between DAL and risk of fractures or BMD, then selected studies following these reported criteria: RRs with corresponding 95% CIs for the relationship between DAL and fracture risk; correlation coefficients for the association between DAL and BMD; and mean ± SD of BMD values across the categories of DAL. Overall, 17 studies with 80545 individuals were included. There was no significant relationship between the PRAL and fracture risk (Pooled RR: 1.18; 95% confidence interval 0.98 to 1.41, I(2) = 60.6%). Moreover, a similar association was observed between the NEAP and fracture risk (Pooled RR: 1.41, 95% CI: 0.79 to 2.52, I(2) = 54.1%). The results of five studies from four publications revealed no significant association between dietary PRAL score and femoral and spinal BMD (WMD femoral = −0.01, 95% confidence interval: −0.02 to 0.01, I(2) = 76.5%; WMD spinal = −0.01, 95% CI: −0.03 to 0.01, I(2) = 56.7%). However, being in the highest category of NEAP was significantly associated with a lower femoral and spinal BMD (WMD femoral = −0.01, 95% CI: −0.02 to −0.00, I(2) = 82.1%; WMD spinal = −0.02, 95% CI: −0.03 to −0.01, I(2) = 93%). It was showed that adopting diets high in acidity was not associated with risk of fractures. We also found a significant negative relationship between NEAP and BMD. However, DAL based on PRAL was not associated with BMD. Frontiers Media S.A. 2022-05-06 /pmc/articles/PMC9120865/ /pubmed/35600825 http://dx.doi.org/10.3389/fnut.2022.869132 Text en Copyright © 2022 Gholami, Naghshi, Samadi, Rasaei and Mirzaei. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Nutrition
Gholami, Fatemeh
Naghshi, Sina
Samadi, Mahsa
Rasaei, Niloufar
Mirzaei, Khadijeh
Dietary Acid Load and Bone Health: A Systematic Review and Meta-Analysis of Observational Studies
title Dietary Acid Load and Bone Health: A Systematic Review and Meta-Analysis of Observational Studies
title_full Dietary Acid Load and Bone Health: A Systematic Review and Meta-Analysis of Observational Studies
title_fullStr Dietary Acid Load and Bone Health: A Systematic Review and Meta-Analysis of Observational Studies
title_full_unstemmed Dietary Acid Load and Bone Health: A Systematic Review and Meta-Analysis of Observational Studies
title_short Dietary Acid Load and Bone Health: A Systematic Review and Meta-Analysis of Observational Studies
title_sort dietary acid load and bone health: a systematic review and meta-analysis of observational studies
topic Nutrition
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9120865/
https://www.ncbi.nlm.nih.gov/pubmed/35600825
http://dx.doi.org/10.3389/fnut.2022.869132
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