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Hippocampal Volume and Plasma Brain-Derived Neurotrophic Factor Levels in Patients With Depression and Healthy Controls

The aim of the present study was to investigate associations between hippocampal subfield volumes and plasma levels of brain-derived neurotrophic factor (BDNF) in patients experiencing a first episode of major depression (MD) (n = 30) as compared to healthy controls (HC) (n = 49). Covariate-adjusted...

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Autores principales: Fujii, Rintaro, Watanabe, Keita, Okamoto, Naomichi, Natsuyama, Tomoya, Tesen, Hirofumi, Igata, Ryohei, Konishi, Yuki, Ikenouchi, Atsuko, Kakeda, Shingo, Yoshimura, Reiji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9120937/
https://www.ncbi.nlm.nih.gov/pubmed/35600081
http://dx.doi.org/10.3389/fnmol.2022.857293
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author Fujii, Rintaro
Watanabe, Keita
Okamoto, Naomichi
Natsuyama, Tomoya
Tesen, Hirofumi
Igata, Ryohei
Konishi, Yuki
Ikenouchi, Atsuko
Kakeda, Shingo
Yoshimura, Reiji
author_facet Fujii, Rintaro
Watanabe, Keita
Okamoto, Naomichi
Natsuyama, Tomoya
Tesen, Hirofumi
Igata, Ryohei
Konishi, Yuki
Ikenouchi, Atsuko
Kakeda, Shingo
Yoshimura, Reiji
author_sort Fujii, Rintaro
collection PubMed
description The aim of the present study was to investigate associations between hippocampal subfield volumes and plasma levels of brain-derived neurotrophic factor (BDNF) in patients experiencing a first episode of major depression (MD) (n = 30) as compared to healthy controls (HC) (n = 49). Covariate-adjusted linear regression was performed to compare the MD and healthy groups, adjusting for age, sex, and total estimated intracranial volume. We demonstrated that there were no differences in total hippocampal volume between the MD and HC groups. However, the volumes of the hippocampus-amygdala-transition-area (HATA) on the left side of the brain as well as the parasubiculum, presubiculum, and fimbria on the right side were statistically significantly smaller in the MD group than in the HC group. Furthermore, the volume of the hippocampal fissure on the right side was statistically significantly smaller in the HC group than in the MD group. In the MD group, we found a positive linear correlation between hippocampal volume and plasma BDNF concentrations in the CA4 area on the left side (p = 0.043). In contrast, in the HC group, we found a negative linear correlation between parasubiculum volume on the right side and plasma BDNF concentrations (p = 0.04). These results suggest that some hippocampal subfields may already be atrophic at the start of MD. In addition, our findings suggest that the sensitivity of the right parasubiculum region to BDNF may differ between MD and HC groups. These findings guide future research directions and, if confirmed, may ultimately inform medical guidelines.
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spelling pubmed-91209372022-05-21 Hippocampal Volume and Plasma Brain-Derived Neurotrophic Factor Levels in Patients With Depression and Healthy Controls Fujii, Rintaro Watanabe, Keita Okamoto, Naomichi Natsuyama, Tomoya Tesen, Hirofumi Igata, Ryohei Konishi, Yuki Ikenouchi, Atsuko Kakeda, Shingo Yoshimura, Reiji Front Mol Neurosci Molecular Neuroscience The aim of the present study was to investigate associations between hippocampal subfield volumes and plasma levels of brain-derived neurotrophic factor (BDNF) in patients experiencing a first episode of major depression (MD) (n = 30) as compared to healthy controls (HC) (n = 49). Covariate-adjusted linear regression was performed to compare the MD and healthy groups, adjusting for age, sex, and total estimated intracranial volume. We demonstrated that there were no differences in total hippocampal volume between the MD and HC groups. However, the volumes of the hippocampus-amygdala-transition-area (HATA) on the left side of the brain as well as the parasubiculum, presubiculum, and fimbria on the right side were statistically significantly smaller in the MD group than in the HC group. Furthermore, the volume of the hippocampal fissure on the right side was statistically significantly smaller in the HC group than in the MD group. In the MD group, we found a positive linear correlation between hippocampal volume and plasma BDNF concentrations in the CA4 area on the left side (p = 0.043). In contrast, in the HC group, we found a negative linear correlation between parasubiculum volume on the right side and plasma BDNF concentrations (p = 0.04). These results suggest that some hippocampal subfields may already be atrophic at the start of MD. In addition, our findings suggest that the sensitivity of the right parasubiculum region to BDNF may differ between MD and HC groups. These findings guide future research directions and, if confirmed, may ultimately inform medical guidelines. Frontiers Media S.A. 2022-05-06 /pmc/articles/PMC9120937/ /pubmed/35600081 http://dx.doi.org/10.3389/fnmol.2022.857293 Text en Copyright © 2022 Fujii, Watanabe, Okamoto, Natsuyama, Tesen, Igata, Konishi, Ikenouchi, Kakeda and Yoshimura. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Molecular Neuroscience
Fujii, Rintaro
Watanabe, Keita
Okamoto, Naomichi
Natsuyama, Tomoya
Tesen, Hirofumi
Igata, Ryohei
Konishi, Yuki
Ikenouchi, Atsuko
Kakeda, Shingo
Yoshimura, Reiji
Hippocampal Volume and Plasma Brain-Derived Neurotrophic Factor Levels in Patients With Depression and Healthy Controls
title Hippocampal Volume and Plasma Brain-Derived Neurotrophic Factor Levels in Patients With Depression and Healthy Controls
title_full Hippocampal Volume and Plasma Brain-Derived Neurotrophic Factor Levels in Patients With Depression and Healthy Controls
title_fullStr Hippocampal Volume and Plasma Brain-Derived Neurotrophic Factor Levels in Patients With Depression and Healthy Controls
title_full_unstemmed Hippocampal Volume and Plasma Brain-Derived Neurotrophic Factor Levels in Patients With Depression and Healthy Controls
title_short Hippocampal Volume and Plasma Brain-Derived Neurotrophic Factor Levels in Patients With Depression and Healthy Controls
title_sort hippocampal volume and plasma brain-derived neurotrophic factor levels in patients with depression and healthy controls
topic Molecular Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9120937/
https://www.ncbi.nlm.nih.gov/pubmed/35600081
http://dx.doi.org/10.3389/fnmol.2022.857293
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