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Editing T cell repertoire by thymic epithelial cell-directed gene transfer abrogates risk of type 1 diabetes development

Insulin is the primary autoantigen (Ag) targeted by T cells in type 1 diabetes (T1D). Although biomarkers precisely identifying subjects at high risk of T1D are available, successful prophylaxis is still an unmet need. Leaky central tolerance to insulin may be partially ascribed to the instability o...

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Detalles Bibliográficos
Autores principales:	Russo, Fabio, Ruggiero, Eliana, Curto, Rosalia, Passeri, Laura, Sanvito, Francesca, Bortolomai, Ileana, Villa, Anna, Gregori, Silvia, Annoni, Andrea
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Gene & Cell Therapy 2022
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9121074/ https://www.ncbi.nlm.nih.gov/pubmed/35615710 http://dx.doi.org/10.1016/j.omtm.2022.04.017

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