Cargando…

The Effect of Vertebral Augmentation Procedure on Painful OVCFs: A Meta-Analysis of Randomized Controlled Trials

STUDY DESIGN: Meta-analysis. OBJECTIVE: To systematically compare the effectiveness and safety of vertebral augmentation procedure (VAP) with non-surgical management (NSM) for the treatment of osteoporotic vertebrate compression fractures (OVCFs). METHODS: Systematic reviews and meta-analyses with t...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Wei-Shang, Cai, Yun-Fei, Cong, Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9121160/
https://www.ncbi.nlm.nih.gov/pubmed/33706568
http://dx.doi.org/10.1177/2192568221999369
_version_ 1784711095911448576
author Li, Wei-Shang
Cai, Yun-Fei
Cong, Lin
author_facet Li, Wei-Shang
Cai, Yun-Fei
Cong, Lin
author_sort Li, Wei-Shang
collection PubMed
description STUDY DESIGN: Meta-analysis. OBJECTIVE: To systematically compare the effectiveness and safety of vertebral augmentation procedure (VAP) with non-surgical management (NSM) for the treatment of osteoporotic vertebrate compression fractures (OVCFs). METHODS: Systematic reviews and meta-analyses with the comparison between VAP and NSM were identified to extract randomized controlled trials from electronic database. Additionally, recently published RCTs were identified. Two researchers independently extracted the data. The primary outcome of this meta-analysis was pain relief evaluated by visual analogue scale (VAS). RESULTS: Twenty RCTs involving 2566 patients with painful OVCFs were included. Significant differences were found between percutaneous vertebroplasty (PVP) and conservative treatment (CT) in VAS at each time point during follow-up period. The differences of VAS were not significant between PVP and sham procedure at most time points during follow-up period. In subgroup analysis based on fracture type and fracture location, significant differences of VAS were found between PVP and CT and were not found between PVP and sham procedure. In subgroup analysis of duration of back pain, significant differences were found between PVP and CT in VAS at 1 week, 3 month and 1 year. And the differences of VAS were not significant between PVP and CT at 1 month and 6 month. CONCLUSION: BKP is considered sufficient to achieve good clinical outcomes. PVP is associated with on beneficial effect on treatment of painful OVCFs compared with sham procedure. The indication and timing of VAP need further research. More independently high-quality RCTs with sufficiently large sample sizes reporting cost-effectiveness are needed.
format Online
Article
Text
id pubmed-9121160
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher SAGE Publications
record_format MEDLINE/PubMed
spelling pubmed-91211602022-05-21 The Effect of Vertebral Augmentation Procedure on Painful OVCFs: A Meta-Analysis of Randomized Controlled Trials Li, Wei-Shang Cai, Yun-Fei Cong, Lin Global Spine J Review Article STUDY DESIGN: Meta-analysis. OBJECTIVE: To systematically compare the effectiveness and safety of vertebral augmentation procedure (VAP) with non-surgical management (NSM) for the treatment of osteoporotic vertebrate compression fractures (OVCFs). METHODS: Systematic reviews and meta-analyses with the comparison between VAP and NSM were identified to extract randomized controlled trials from electronic database. Additionally, recently published RCTs were identified. Two researchers independently extracted the data. The primary outcome of this meta-analysis was pain relief evaluated by visual analogue scale (VAS). RESULTS: Twenty RCTs involving 2566 patients with painful OVCFs were included. Significant differences were found between percutaneous vertebroplasty (PVP) and conservative treatment (CT) in VAS at each time point during follow-up period. The differences of VAS were not significant between PVP and sham procedure at most time points during follow-up period. In subgroup analysis based on fracture type and fracture location, significant differences of VAS were found between PVP and CT and were not found between PVP and sham procedure. In subgroup analysis of duration of back pain, significant differences were found between PVP and CT in VAS at 1 week, 3 month and 1 year. And the differences of VAS were not significant between PVP and CT at 1 month and 6 month. CONCLUSION: BKP is considered sufficient to achieve good clinical outcomes. PVP is associated with on beneficial effect on treatment of painful OVCFs compared with sham procedure. The indication and timing of VAP need further research. More independently high-quality RCTs with sufficiently large sample sizes reporting cost-effectiveness are needed. SAGE Publications 2021-03-11 2022-04 /pmc/articles/PMC9121160/ /pubmed/33706568 http://dx.doi.org/10.1177/2192568221999369 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by-nc-nd/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 License (https://creativecommons.org/licenses/by-nc-nd/4.0/) which permits non-commercial use, reproduction and distribution of the work as published without adaptation or alteration, without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Review Article
Li, Wei-Shang
Cai, Yun-Fei
Cong, Lin
The Effect of Vertebral Augmentation Procedure on Painful OVCFs: A Meta-Analysis of Randomized Controlled Trials
title The Effect of Vertebral Augmentation Procedure on Painful OVCFs: A Meta-Analysis of Randomized Controlled Trials
title_full The Effect of Vertebral Augmentation Procedure on Painful OVCFs: A Meta-Analysis of Randomized Controlled Trials
title_fullStr The Effect of Vertebral Augmentation Procedure on Painful OVCFs: A Meta-Analysis of Randomized Controlled Trials
title_full_unstemmed The Effect of Vertebral Augmentation Procedure on Painful OVCFs: A Meta-Analysis of Randomized Controlled Trials
title_short The Effect of Vertebral Augmentation Procedure on Painful OVCFs: A Meta-Analysis of Randomized Controlled Trials
title_sort effect of vertebral augmentation procedure on painful ovcfs: a meta-analysis of randomized controlled trials
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9121160/
https://www.ncbi.nlm.nih.gov/pubmed/33706568
http://dx.doi.org/10.1177/2192568221999369
work_keys_str_mv AT liweishang theeffectofvertebralaugmentationprocedureonpainfulovcfsametaanalysisofrandomizedcontrolledtrials
AT caiyunfei theeffectofvertebralaugmentationprocedureonpainfulovcfsametaanalysisofrandomizedcontrolledtrials
AT conglin theeffectofvertebralaugmentationprocedureonpainfulovcfsametaanalysisofrandomizedcontrolledtrials
AT liweishang effectofvertebralaugmentationprocedureonpainfulovcfsametaanalysisofrandomizedcontrolledtrials
AT caiyunfei effectofvertebralaugmentationprocedureonpainfulovcfsametaanalysisofrandomizedcontrolledtrials
AT conglin effectofvertebralaugmentationprocedureonpainfulovcfsametaanalysisofrandomizedcontrolledtrials