Cargando…
Pomegranate seed oil protects against tacrolimus-induced toxicity in the heart and kidney by modulation of oxidative stress in rats
OBJECTIVE: The clinical use of tacrolimus is limited due to its side effects. This research investigated the protective activities of pomegranate seed oil (PSO) against TAC toxicity. MATERIALS AND METHODS: The groups are included normal (1 ml of corn oil), TAC (2 mg/kg), and co-treatment of PSO (0.4...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Mashhad University of Medical Sciences
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9121255/ https://www.ncbi.nlm.nih.gov/pubmed/35782771 http://dx.doi.org/10.22038/AJP.2022.19703 |
_version_ | 1784711117821444096 |
---|---|
author | Hosseini, Azar Rajabian, Arezoo Forouzanfar, Fatemeh Farzadnia, Mahdi Boroushaki, Mohammad Taher |
author_facet | Hosseini, Azar Rajabian, Arezoo Forouzanfar, Fatemeh Farzadnia, Mahdi Boroushaki, Mohammad Taher |
author_sort | Hosseini, Azar |
collection | PubMed |
description | OBJECTIVE: The clinical use of tacrolimus is limited due to its side effects. This research investigated the protective activities of pomegranate seed oil (PSO) against TAC toxicity. MATERIALS AND METHODS: The groups are included normal (1 ml of corn oil), TAC (2 mg/kg), and co-treatment of PSO (0.4 and 0.8 ml/kg) and TAC. All administrations were carried out intraperitoneally for 14 days. After the last injection, blood was collected from the heart. RESULTS: TAC increased creatinine and urea. Increased malondialdehyde, reduced thiol content and superoxide dismutase. The elevation of lactate dehydrogenase, aspartate aminotransferase (AST), alanine aminotransferase (ALT), creatinine kinase-MB and creatinine phosphokinase that confirmed cardiac toxicity. PSO reduced TAC toxicity. PSO decreased TAC-induced pathology injury. CONCLUSION: PSO reduced TAC toxicity in renal and heart via scavenging free radicals. |
format | Online Article Text |
id | pubmed-9121255 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Mashhad University of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-91212552022-07-01 Pomegranate seed oil protects against tacrolimus-induced toxicity in the heart and kidney by modulation of oxidative stress in rats Hosseini, Azar Rajabian, Arezoo Forouzanfar, Fatemeh Farzadnia, Mahdi Boroushaki, Mohammad Taher Avicenna J Phytomed Original Research Article OBJECTIVE: The clinical use of tacrolimus is limited due to its side effects. This research investigated the protective activities of pomegranate seed oil (PSO) against TAC toxicity. MATERIALS AND METHODS: The groups are included normal (1 ml of corn oil), TAC (2 mg/kg), and co-treatment of PSO (0.4 and 0.8 ml/kg) and TAC. All administrations were carried out intraperitoneally for 14 days. After the last injection, blood was collected from the heart. RESULTS: TAC increased creatinine and urea. Increased malondialdehyde, reduced thiol content and superoxide dismutase. The elevation of lactate dehydrogenase, aspartate aminotransferase (AST), alanine aminotransferase (ALT), creatinine kinase-MB and creatinine phosphokinase that confirmed cardiac toxicity. PSO reduced TAC toxicity. PSO decreased TAC-induced pathology injury. CONCLUSION: PSO reduced TAC toxicity in renal and heart via scavenging free radicals. Mashhad University of Medical Sciences 2022 /pmc/articles/PMC9121255/ /pubmed/35782771 http://dx.doi.org/10.22038/AJP.2022.19703 Text en https://creativecommons.org/licenses/by/3.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/ (https://creativecommons.org/licenses/by/3.0/) ) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Research Article Hosseini, Azar Rajabian, Arezoo Forouzanfar, Fatemeh Farzadnia, Mahdi Boroushaki, Mohammad Taher Pomegranate seed oil protects against tacrolimus-induced toxicity in the heart and kidney by modulation of oxidative stress in rats |
title | Pomegranate seed oil protects against tacrolimus-induced toxicity in the heart and kidney by modulation of oxidative stress in rats |
title_full | Pomegranate seed oil protects against tacrolimus-induced toxicity in the heart and kidney by modulation of oxidative stress in rats |
title_fullStr | Pomegranate seed oil protects against tacrolimus-induced toxicity in the heart and kidney by modulation of oxidative stress in rats |
title_full_unstemmed | Pomegranate seed oil protects against tacrolimus-induced toxicity in the heart and kidney by modulation of oxidative stress in rats |
title_short | Pomegranate seed oil protects against tacrolimus-induced toxicity in the heart and kidney by modulation of oxidative stress in rats |
title_sort | pomegranate seed oil protects against tacrolimus-induced toxicity in the heart and kidney by modulation of oxidative stress in rats |
topic | Original Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9121255/ https://www.ncbi.nlm.nih.gov/pubmed/35782771 http://dx.doi.org/10.22038/AJP.2022.19703 |
work_keys_str_mv | AT hosseiniazar pomegranateseedoilprotectsagainsttacrolimusinducedtoxicityintheheartandkidneybymodulationofoxidativestressinrats AT rajabianarezoo pomegranateseedoilprotectsagainsttacrolimusinducedtoxicityintheheartandkidneybymodulationofoxidativestressinrats AT forouzanfarfatemeh pomegranateseedoilprotectsagainsttacrolimusinducedtoxicityintheheartandkidneybymodulationofoxidativestressinrats AT farzadniamahdi pomegranateseedoilprotectsagainsttacrolimusinducedtoxicityintheheartandkidneybymodulationofoxidativestressinrats AT boroushakimohammadtaher pomegranateseedoilprotectsagainsttacrolimusinducedtoxicityintheheartandkidneybymodulationofoxidativestressinrats |