Mutational profiling of mtDNA control region reveals tumor-specific evolutionary selection involved in mitochondrial dysfunction

BACKGROUND: Mitochondrial DNA (mtDNA) mutations alter mitochondrial function in oxidative metabolism and play an important role in tumorigenesis. A series of studies have demonstrated that the mtDNA control region (mtCTR), which is essential for mtDNA replication and transcription, represents a muta...

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Detalles Bibliográficos
Autores principales: Ji, Xiaoying, Guo, Wenjie, Gu, Xiwen, Guo, Shanshan, Zhou, Kaixiang, Su, Liping, Yuan, Qing, Liu, Yang, Guo, Xu, Huang, Qichao, Xing, Jinliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9121266/
https://www.ncbi.nlm.nih.gov/pubmed/35594659
http://dx.doi.org/10.1016/j.ebiom.2022.104058

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