Phenotypic Screening Using High-Content Imaging to Identify Lysosomal pH Modulators in a Neuronal Cell Model

[Image: see text] Lysosomes are intracellular organelles responsible for the degradation of diverse macromolecules in a cell. A highly acidic pH is required for the optimal functioning of lysosomal enzymes. Loss of lysosomal intralumenal acidity can disrupt cellular protein homeostasis and is linked...

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Detalles Bibliográficos
Autores principales: Chin, Marcus Y., Ang, Kean-Hooi, Davies, Julia, Alquezar, Carolina, Garda, Virginia G., Rooney, Brendan, Leng, Kun, Kampmann, Martin, Arkin, Michelle R., Kao, Aimee W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9121341/
https://www.ncbi.nlm.nih.gov/pubmed/35522480
http://dx.doi.org/10.1021/acschemneuro.1c00804

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9121341/
https://www.ncbi.nlm.nih.gov/pubmed/35522480
http://dx.doi.org/10.1021/acschemneuro.1c00804

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