Cargando…

Phenotypic Screening Using High-Content Imaging to Identify Lysosomal pH Modulators in a Neuronal Cell Model

[Image: see text] Lysosomes are intracellular organelles responsible for the degradation of diverse macromolecules in a cell. A highly acidic pH is required for the optimal functioning of lysosomal enzymes. Loss of lysosomal intralumenal acidity can disrupt cellular protein homeostasis and is linked...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chin, Marcus Y., Ang, Kean-Hooi, Davies, Julia, Alquezar, Carolina, Garda, Virginia G., Rooney, Brendan, Leng, Kun, Kampmann, Martin, Arkin, Michelle R., Kao, Aimee W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2022
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9121341/ https://www.ncbi.nlm.nih.gov/pubmed/35522480 http://dx.doi.org/10.1021/acschemneuro.1c00804

Ejemplares similares

Genetically Encoded, pH-Sensitive mTFP1 Biosensor for Probing Lysosomal pH
por: Chin, Marcus Y., et al.
Publicado: (2021)

Caveolin targeting to late endosome/lysosomal membranes is induced by perturbations of lysosomal pH and cholesterol content
por: Mundy, Dorothy I., et al.
Publicado: (2012)

Tau Post-translational Modifications: Dynamic Transformers of Tau Function, Degradation, and Aggregation
por: Alquezar, Carolina, et al.
Publicado: (2021)

Stress Resistance Screen in a Human Primary Cell Line Identifies Small Molecules That Affect Aging Pathways and Extend Caenorhabditis elegans’ Lifespan
por: Zhang, Peichuan, et al.
Publicado: (2019)

Glutamine Produces Ammonium to Tune Lysosomal pH and Regulate Lysosomal Function
por: Xiong, Jian, et al.
Publicado: (2022)

A model of lysosomal pH regulation
por: Ishida, Yoichi, et al.
Publicado: (2013)

A High-Throughput Functional Screen Identifies Small Molecule Regulators of Temperature- and Mechano-Sensitive K(2P) Channels
por: Bagriantsev, Sviatoslav N., et al.
Publicado: (2013)

Structure of human saposin A at lysosomal pH
por: Hill, Chris H., et al.
Publicado: (2015)

Sensitivity to Lysosome-Dependent Cell Death Is Directly Regulated by Lysosomal Cholesterol Content
por: Appelqvist, Hanna, et al.
Publicado: (2012)

The position of lysosomes within the cell determines their luminal pH
por: Johnson, Danielle E., et al.
Publicado: (2016)

Lysosome as a Central Hub for Rewiring PH Homeostasis in Tumors
por: Chen, Ran, et al.
Publicado: (2020)

Two Pore Channel 2 (TPC2) Inhibits Autophagosomal-Lysosomal Fusion by Alkalinizing Lysosomal pH
por: Lu, Yingying, et al.
Publicado: (2013)

Acidic Nanoparticles Are Trafficked to Lysosomes and Restore an Acidic Lysosomal pH and Degradative Function to Compromised ARPE-19 Cells
por: Baltazar, Gabriel C., et al.
Publicado: (2012)

Changes in lysosome shape and distribution correlated with changes in cytoplasmic pH
Publicado: (1989)

Lysosomal pH and analysis of the counter ion pathways that support acidification
por: DiCiccio, Jessica E., et al.
Publicado: (2011)

The endoplasmic reticulum, not the pH gradient, drives calcium refilling of lysosomes
por: Garrity, Abigail G, et al.
Publicado: (2016)

Bioimaging of Lysosomes with a BODIPY pH-Dependent Fluorescent Probe
por: Gonçalves, Raquel C. R., et al.
Publicado: (2022)

Towards elucidating disease-relevant states of neurons and glia by CRISPR-based functional genomics
por: Leng, Kun, et al.
Publicado: (2022)

Lysosomal oxidation of LDL alters lysosomal pH, induces senescence, and increases secretion of pro-inflammatory cytokines in human macrophages
por: Ahmad, Feroz, et al.
Publicado: (2019)

Ceapins are a new class of unfolded protein response inhibitors, selectively targeting the ATF6α branch
por: Gallagher, Ciara M, et al.
Publicado: (2016)

Oxidation of Low-Density Lipoprotein by Iron at Lysosomal pH: Implications for Atherosclerosis
por: Satchell, Leanne, et al.
Publicado: (2012)

Sorting and Trafficking in the Endo-Lysosomal System: An Interview with Chris Burd, PhD
por: Qiu, Jingyao
Publicado: (2019)

Rhodamine-Based Cyclic Hydroxamate as Fluorescent pH Probe for Imaging of Lysosomes
por: Kim, Young Ju, et al.
Publicado: (2023)

Chinese hamster ovary cell lysosomes rapidly exchange contents
Publicado: (1987)

Cholesterol content regulates silica-induced lysosomal membrane permeability
por: Sydor, Matthew J., et al.
Publicado: (2023)

Determinants of pH profile and acyl chain selectivity in lysosomal phospholipase A(2)
por: Hinkovska-Galcheva, Vania, et al.
Publicado: (2018)

STAT3 associates with vacuolar H(+)-ATPase and regulates cytosolic and lysosomal pH
por: Liu, Bin, et al.
Publicado: (2018)

Alginate oligosaccharides can maintain activities of lysosomes under low pH condition
por: Park, Ra-Mi, et al.
Publicado: (2021)

Heavy metals contaminating the environment of a progressive supranuclear palsy cluster induce tau accumulation and cell death in cultured neurons
por: Alquezar, Carolina, et al.
Publicado: (2020)

Tau fibrils induce nanoscale membrane damage and nucleate cytosolic tau at lysosomes
por: Rose, Kevin, et al.
Publicado: (2023)

An acidic pH independent piperazine–TPE AIEgen as a unique bioprobe for lysosome tracing
por: Cai, Yuanjing, et al.
Publicado: (2017)

The Establishment and Application Studies on Precise Lysosome pH Indicator Based on Self-Decomposable Nanoparticles
por: Pang, Cui, et al.
Publicado: (2020)

Control of lysosomal-mediated cell death by the pH-dependent calcium channel RECS1
por: Pihán, Philippe, et al.
Publicado: (2021)

pHLARE: a new biosensor reveals decreased lysosome pH in cancer cells
por: Webb, Bradley A., et al.
Publicado: (2021)

A Multifunctional and Fast-Response Lysosome-Targetable Fluorescent Probe for Monitoring pH and Isoxaflutole
por: Yang, Liu, et al.
Publicado: (2022)

Imaging-based chemical screening reveals activity-dependent neural differentiation of pluripotent stem cells
por: Sun, Yaping, et al.
Publicado: (2013)

pH induced conformational alteration in human peroxiredoxin 6 might be responsible for its resistance against lysosomal pH or high temperature
por: Chowhan, Rimpy Kaur, et al.
Publicado: (2021)

Lysosomes and Lysosomal Storage Diseases
por: Noebels, Jeffrey L.
Publicado: (1981)

Endocytosis of DNA-Hsp65 Alters the pH of the Late Endosome/Lysosome and Interferes with Antigen Presentation
por: Trombone, Ana Paula F., et al.
Publicado: (2007)

Intralysosomal accumulation of polyanions. II. Polyanion internalization and its influence on lysosomal pH and membrane fluidity
Publicado: (1982)

Cannot write session to /tmp/vufind_sessions/sess_a46t4ighslkj72qolsr4r51gms