Neuroprotective Effect of Carnosine Is Mediated by Insulin-Degrading Enzyme

[Image: see text] l-Carnosine is an endogenous dipeptide that has high potential for therapeutic purposes, being an antioxidant with metal chelating, anti-aggregating, anti-inflammatory, and neuroprotective properties. Despite its potential therapeutic values, the biomolecular mechanisms involved in...

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Autores principales: Distefano, Alessia, Caruso, Giuseppe, Oliveri, Valentina, Bellia, Francesco, Sbardella, Diego, Zingale, Gabriele Antonio, Caraci, Filippo, Grasso, Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9121383/
https://www.ncbi.nlm.nih.gov/pubmed/35471926
http://dx.doi.org/10.1021/acschemneuro.2c00201
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author Distefano, Alessia
Caruso, Giuseppe
Oliveri, Valentina
Bellia, Francesco
Sbardella, Diego
Zingale, Gabriele Antonio
Caraci, Filippo
Grasso, Giuseppe
author_facet Distefano, Alessia
Caruso, Giuseppe
Oliveri, Valentina
Bellia, Francesco
Sbardella, Diego
Zingale, Gabriele Antonio
Caraci, Filippo
Grasso, Giuseppe
author_sort Distefano, Alessia
collection PubMed
description [Image: see text] l-Carnosine is an endogenous dipeptide that has high potential for therapeutic purposes, being an antioxidant with metal chelating, anti-aggregating, anti-inflammatory, and neuroprotective properties. Despite its potential therapeutic values, the biomolecular mechanisms involved in neuroprotection are not fully understood. Here, we demonstrate, at chemical and biochemical levels, that insulin-degrading enzyme plays a pivotal role in carnosine neuroprotection.
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spelling pubmed-91213832022-05-21 Neuroprotective Effect of Carnosine Is Mediated by Insulin-Degrading Enzyme Distefano, Alessia Caruso, Giuseppe Oliveri, Valentina Bellia, Francesco Sbardella, Diego Zingale, Gabriele Antonio Caraci, Filippo Grasso, Giuseppe ACS Chem Neurosci [Image: see text] l-Carnosine is an endogenous dipeptide that has high potential for therapeutic purposes, being an antioxidant with metal chelating, anti-aggregating, anti-inflammatory, and neuroprotective properties. Despite its potential therapeutic values, the biomolecular mechanisms involved in neuroprotection are not fully understood. Here, we demonstrate, at chemical and biochemical levels, that insulin-degrading enzyme plays a pivotal role in carnosine neuroprotection. American Chemical Society 2022-04-26 /pmc/articles/PMC9121383/ /pubmed/35471926 http://dx.doi.org/10.1021/acschemneuro.2c00201 Text en © 2022 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by/4.0/Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Distefano, Alessia
Caruso, Giuseppe
Oliveri, Valentina
Bellia, Francesco
Sbardella, Diego
Zingale, Gabriele Antonio
Caraci, Filippo
Grasso, Giuseppe
Neuroprotective Effect of Carnosine Is Mediated by Insulin-Degrading Enzyme
title Neuroprotective Effect of Carnosine Is Mediated by Insulin-Degrading Enzyme
title_full Neuroprotective Effect of Carnosine Is Mediated by Insulin-Degrading Enzyme
title_fullStr Neuroprotective Effect of Carnosine Is Mediated by Insulin-Degrading Enzyme
title_full_unstemmed Neuroprotective Effect of Carnosine Is Mediated by Insulin-Degrading Enzyme
title_short Neuroprotective Effect of Carnosine Is Mediated by Insulin-Degrading Enzyme
title_sort neuroprotective effect of carnosine is mediated by insulin-degrading enzyme
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9121383/
https://www.ncbi.nlm.nih.gov/pubmed/35471926
http://dx.doi.org/10.1021/acschemneuro.2c00201
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