Chemical Proteomics of the Tumor Suppressor Fhit Covalently Bound to the Cofactor Ap(3)A Elucidates Its Inhibitory Action on Translation

[Image: see text] The tumor suppressor protein fragile histidine triad (Fhit) is known to be associated with genomic instability and apoptosis. The tumor-suppressive function of Fhit depends on the interaction with the alarmone diadenosine triphosphate (Ap(3)A), a noncanonical nucleotide whose conce...

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Detalles Bibliográficos
Autores principales: Herzog, Doreen, Jansen, Jasmin, Mißun, Maite, Diederichs, Kay, Stengel, Florian, Marx, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9121386/
https://www.ncbi.nlm.nih.gov/pubmed/35522782
http://dx.doi.org/10.1021/jacs.2c00815

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