Silencing alanine transaminase 2 in diabetic liver attenuates hyperglycemia by reducing gluconeogenesis from amino acids

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Hepatic gluconeogenesis from amino acids contributes significantly to diabetic hyperglycemia, but the molecular mechanisms involved are incompletely understood. Alanine transaminases (ALT1 and ALT2) catalyze the interconversion of alanine and pyruvate, which is required for gluconeogenesis from alan...

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Detalles Bibliográficos
Autores principales: Martino, Michael R., Gutiérrez-Aguilar, Manuel, Yiew, Nicole K.H., Lutkewitte, Andrew J., Singer, Jason M., McCommis, Kyle S., Ferguson, Daniel, Liss, Kim H.H., Yoshino, Jun, Renkemeyer, M. Katie, Smith, Gordon I., Cho, Kevin, Fletcher, Justin A., Klein, Samuel, Patti, Gary J., Burgess, Shawn C., Finck, Brian N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9121396/
https://www.ncbi.nlm.nih.gov/pubmed/35476997
http://dx.doi.org/10.1016/j.celrep.2022.110733
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