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Advances in the Study of Circadian Genes in Non-Small Cell Lung Cancer
Circadian genes regulate several physiological functions such as circadian rhythm and metabolism and participate in the cytogenesis and progression of various malignancies. The abnormal expression of these genes in non-small cell lung cancer (NSCLC) is closely related to the clinicopathological feat...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9121494/ https://www.ncbi.nlm.nih.gov/pubmed/35575281 http://dx.doi.org/10.1177/15347354221096080 |
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author | Zhang, Hao Liu, Renwang Zhang, Bo Huo, Huandong Song, Zuoqing |
author_facet | Zhang, Hao Liu, Renwang Zhang, Bo Huo, Huandong Song, Zuoqing |
author_sort | Zhang, Hao |
collection | PubMed |
description | Circadian genes regulate several physiological functions such as circadian rhythm and metabolism and participate in the cytogenesis and progression of various malignancies. The abnormal expression of these genes in non-small cell lung cancer (NSCLC) is closely related to the clinicopathological features of NSCLC and may promote or inhibit NSCLC progression. Circadian rhythm disorders and clock gene abnormalities may increase the risk of lung cancer in some populations. We collected 15 circadian genes in NSCLC, namely PER1, PER2, PER3, TIMELESS, Cry1, Cry2, CLOCK, BMAL1/ARNTL-1, ARNTL2, NPAS2, NR1D1(REV-ERB), DEC1, DEC2, RORα, and RORγ, and determined their relationships with the clinicopathological features of patients and the potential mechanisms promoting or inhibiting NSCLC progression. We also summarized the studies on circadian rhythm disorders and circadian genes associated with lung cancer risk. The present study aimed to provide theoretical support for the future exploration of new therapeutic targets and for the primary prevention of NSCLC from the perspective of circadian genes. Interpretation of circadian rhythms in lung cancer could guide further lung cancer mechanism research and drug development that could lead to more effective treatments and improve patient outcomes. |
format | Online Article Text |
id | pubmed-9121494 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-91214942022-05-21 Advances in the Study of Circadian Genes in Non-Small Cell Lung Cancer Zhang, Hao Liu, Renwang Zhang, Bo Huo, Huandong Song, Zuoqing Integr Cancer Ther Review Article Circadian genes regulate several physiological functions such as circadian rhythm and metabolism and participate in the cytogenesis and progression of various malignancies. The abnormal expression of these genes in non-small cell lung cancer (NSCLC) is closely related to the clinicopathological features of NSCLC and may promote or inhibit NSCLC progression. Circadian rhythm disorders and clock gene abnormalities may increase the risk of lung cancer in some populations. We collected 15 circadian genes in NSCLC, namely PER1, PER2, PER3, TIMELESS, Cry1, Cry2, CLOCK, BMAL1/ARNTL-1, ARNTL2, NPAS2, NR1D1(REV-ERB), DEC1, DEC2, RORα, and RORγ, and determined their relationships with the clinicopathological features of patients and the potential mechanisms promoting or inhibiting NSCLC progression. We also summarized the studies on circadian rhythm disorders and circadian genes associated with lung cancer risk. The present study aimed to provide theoretical support for the future exploration of new therapeutic targets and for the primary prevention of NSCLC from the perspective of circadian genes. Interpretation of circadian rhythms in lung cancer could guide further lung cancer mechanism research and drug development that could lead to more effective treatments and improve patient outcomes. SAGE Publications 2022-05-16 /pmc/articles/PMC9121494/ /pubmed/35575281 http://dx.doi.org/10.1177/15347354221096080 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Review Article Zhang, Hao Liu, Renwang Zhang, Bo Huo, Huandong Song, Zuoqing Advances in the Study of Circadian Genes in Non-Small Cell Lung Cancer |
title | Advances in the Study of Circadian Genes in Non-Small Cell Lung
Cancer |
title_full | Advances in the Study of Circadian Genes in Non-Small Cell Lung
Cancer |
title_fullStr | Advances in the Study of Circadian Genes in Non-Small Cell Lung
Cancer |
title_full_unstemmed | Advances in the Study of Circadian Genes in Non-Small Cell Lung
Cancer |
title_short | Advances in the Study of Circadian Genes in Non-Small Cell Lung
Cancer |
title_sort | advances in the study of circadian genes in non-small cell lung
cancer |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9121494/ https://www.ncbi.nlm.nih.gov/pubmed/35575281 http://dx.doi.org/10.1177/15347354221096080 |
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