Cargando…
MicroRNAs in peripheral artery disease: potential biomarkers and pathophysiological mechanisms
Peripheral artery disease (PAD) is a disease of atherosclerosis in the lower extremities. PAD carries a massive burden worldwide, while diagnosis and treatment options are often lacking. One of the key points of research in recent years is the involvement of microRNAs (miRNAs), which are short 20-25...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9121511/ https://www.ncbi.nlm.nih.gov/pubmed/35583375 http://dx.doi.org/10.1177/17539447221096940 |
_version_ | 1784711166140874752 |
---|---|
author | Ring, Andrew Ismaeel, Ahmed Wechsler, Marissa Fletcher, Emma Papoutsi, Evlampia Miserlis, Dimitrios Koutakis, Panagiotis |
author_facet | Ring, Andrew Ismaeel, Ahmed Wechsler, Marissa Fletcher, Emma Papoutsi, Evlampia Miserlis, Dimitrios Koutakis, Panagiotis |
author_sort | Ring, Andrew |
collection | PubMed |
description | Peripheral artery disease (PAD) is a disease of atherosclerosis in the lower extremities. PAD carries a massive burden worldwide, while diagnosis and treatment options are often lacking. One of the key points of research in recent years is the involvement of microRNAs (miRNAs), which are short 20-25 nucleotide single-stranded RNAs that can act as negative regulators of post-transcriptional gene expression. Many of these miRNAs have been discovered to be misregulated in PAD patients, suggesting a potential utility as biomarkers for PAD diagnosis. miRNAs have also been shown to play an important role in many different pathophysiological aspects involved in the initiation and progression of the disease including angiogenesis, hypoxia, inflammation, as well as other cellular functions like cell proliferation and migration. The research on miRNAs in PAD has the potential to lead to a whole new class of diagnostic tools and treatments. |
format | Online Article Text |
id | pubmed-9121511 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-91215112022-05-21 MicroRNAs in peripheral artery disease: potential biomarkers and pathophysiological mechanisms Ring, Andrew Ismaeel, Ahmed Wechsler, Marissa Fletcher, Emma Papoutsi, Evlampia Miserlis, Dimitrios Koutakis, Panagiotis Ther Adv Cardiovasc Dis Review Peripheral artery disease (PAD) is a disease of atherosclerosis in the lower extremities. PAD carries a massive burden worldwide, while diagnosis and treatment options are often lacking. One of the key points of research in recent years is the involvement of microRNAs (miRNAs), which are short 20-25 nucleotide single-stranded RNAs that can act as negative regulators of post-transcriptional gene expression. Many of these miRNAs have been discovered to be misregulated in PAD patients, suggesting a potential utility as biomarkers for PAD diagnosis. miRNAs have also been shown to play an important role in many different pathophysiological aspects involved in the initiation and progression of the disease including angiogenesis, hypoxia, inflammation, as well as other cellular functions like cell proliferation and migration. The research on miRNAs in PAD has the potential to lead to a whole new class of diagnostic tools and treatments. SAGE Publications 2022-05-18 /pmc/articles/PMC9121511/ /pubmed/35583375 http://dx.doi.org/10.1177/17539447221096940 Text en © The Author(s), 2022 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Review Ring, Andrew Ismaeel, Ahmed Wechsler, Marissa Fletcher, Emma Papoutsi, Evlampia Miserlis, Dimitrios Koutakis, Panagiotis MicroRNAs in peripheral artery disease: potential biomarkers and pathophysiological mechanisms |
title | MicroRNAs in peripheral artery disease: potential biomarkers and
pathophysiological mechanisms |
title_full | MicroRNAs in peripheral artery disease: potential biomarkers and
pathophysiological mechanisms |
title_fullStr | MicroRNAs in peripheral artery disease: potential biomarkers and
pathophysiological mechanisms |
title_full_unstemmed | MicroRNAs in peripheral artery disease: potential biomarkers and
pathophysiological mechanisms |
title_short | MicroRNAs in peripheral artery disease: potential biomarkers and
pathophysiological mechanisms |
title_sort | micrornas in peripheral artery disease: potential biomarkers and
pathophysiological mechanisms |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9121511/ https://www.ncbi.nlm.nih.gov/pubmed/35583375 http://dx.doi.org/10.1177/17539447221096940 |
work_keys_str_mv | AT ringandrew micrornasinperipheralarterydiseasepotentialbiomarkersandpathophysiologicalmechanisms AT ismaeelahmed micrornasinperipheralarterydiseasepotentialbiomarkersandpathophysiologicalmechanisms AT wechslermarissa micrornasinperipheralarterydiseasepotentialbiomarkersandpathophysiologicalmechanisms AT fletcheremma micrornasinperipheralarterydiseasepotentialbiomarkersandpathophysiologicalmechanisms AT papoutsievlampia micrornasinperipheralarterydiseasepotentialbiomarkersandpathophysiologicalmechanisms AT miserlisdimitrios micrornasinperipheralarterydiseasepotentialbiomarkersandpathophysiologicalmechanisms AT koutakispanagiotis micrornasinperipheralarterydiseasepotentialbiomarkersandpathophysiologicalmechanisms |