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MicroRNAs in peripheral artery disease: potential biomarkers and pathophysiological mechanisms

Peripheral artery disease (PAD) is a disease of atherosclerosis in the lower extremities. PAD carries a massive burden worldwide, while diagnosis and treatment options are often lacking. One of the key points of research in recent years is the involvement of microRNAs (miRNAs), which are short 20-25...

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Autores principales: Ring, Andrew, Ismaeel, Ahmed, Wechsler, Marissa, Fletcher, Emma, Papoutsi, Evlampia, Miserlis, Dimitrios, Koutakis, Panagiotis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9121511/
https://www.ncbi.nlm.nih.gov/pubmed/35583375
http://dx.doi.org/10.1177/17539447221096940
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author Ring, Andrew
Ismaeel, Ahmed
Wechsler, Marissa
Fletcher, Emma
Papoutsi, Evlampia
Miserlis, Dimitrios
Koutakis, Panagiotis
author_facet Ring, Andrew
Ismaeel, Ahmed
Wechsler, Marissa
Fletcher, Emma
Papoutsi, Evlampia
Miserlis, Dimitrios
Koutakis, Panagiotis
author_sort Ring, Andrew
collection PubMed
description Peripheral artery disease (PAD) is a disease of atherosclerosis in the lower extremities. PAD carries a massive burden worldwide, while diagnosis and treatment options are often lacking. One of the key points of research in recent years is the involvement of microRNAs (miRNAs), which are short 20-25 nucleotide single-stranded RNAs that can act as negative regulators of post-transcriptional gene expression. Many of these miRNAs have been discovered to be misregulated in PAD patients, suggesting a potential utility as biomarkers for PAD diagnosis. miRNAs have also been shown to play an important role in many different pathophysiological aspects involved in the initiation and progression of the disease including angiogenesis, hypoxia, inflammation, as well as other cellular functions like cell proliferation and migration. The research on miRNAs in PAD has the potential to lead to a whole new class of diagnostic tools and treatments.
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spelling pubmed-91215112022-05-21 MicroRNAs in peripheral artery disease: potential biomarkers and pathophysiological mechanisms Ring, Andrew Ismaeel, Ahmed Wechsler, Marissa Fletcher, Emma Papoutsi, Evlampia Miserlis, Dimitrios Koutakis, Panagiotis Ther Adv Cardiovasc Dis Review Peripheral artery disease (PAD) is a disease of atherosclerosis in the lower extremities. PAD carries a massive burden worldwide, while diagnosis and treatment options are often lacking. One of the key points of research in recent years is the involvement of microRNAs (miRNAs), which are short 20-25 nucleotide single-stranded RNAs that can act as negative regulators of post-transcriptional gene expression. Many of these miRNAs have been discovered to be misregulated in PAD patients, suggesting a potential utility as biomarkers for PAD diagnosis. miRNAs have also been shown to play an important role in many different pathophysiological aspects involved in the initiation and progression of the disease including angiogenesis, hypoxia, inflammation, as well as other cellular functions like cell proliferation and migration. The research on miRNAs in PAD has the potential to lead to a whole new class of diagnostic tools and treatments. SAGE Publications 2022-05-18 /pmc/articles/PMC9121511/ /pubmed/35583375 http://dx.doi.org/10.1177/17539447221096940 Text en © The Author(s), 2022 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Review
Ring, Andrew
Ismaeel, Ahmed
Wechsler, Marissa
Fletcher, Emma
Papoutsi, Evlampia
Miserlis, Dimitrios
Koutakis, Panagiotis
MicroRNAs in peripheral artery disease: potential biomarkers and pathophysiological mechanisms
title MicroRNAs in peripheral artery disease: potential biomarkers and pathophysiological mechanisms
title_full MicroRNAs in peripheral artery disease: potential biomarkers and pathophysiological mechanisms
title_fullStr MicroRNAs in peripheral artery disease: potential biomarkers and pathophysiological mechanisms
title_full_unstemmed MicroRNAs in peripheral artery disease: potential biomarkers and pathophysiological mechanisms
title_short MicroRNAs in peripheral artery disease: potential biomarkers and pathophysiological mechanisms
title_sort micrornas in peripheral artery disease: potential biomarkers and pathophysiological mechanisms
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9121511/
https://www.ncbi.nlm.nih.gov/pubmed/35583375
http://dx.doi.org/10.1177/17539447221096940
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