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Comparison of Gene Expression Profiles of Signet Ring Cell Carcinoma and Poorly Cohesive Carcinoma in Early Gastric Cancer

INTRODUCTION: Although signet ring cell carcinoma (SRC) is a subtype of poorly cohesive carcinoma (PC), the differences in the biological behavior between the 2 morphologically similar carcinomas have not been fully studied. Therefore, we performed transcriptome analysis to evaluate the differences...

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Autores principales: Yeo, Min Kyung, Kang, Sun Hyung, Jeong, Ku Bean, Lee, Hyun Seok, Jeon, Hong Jae, Eun, Hyuk Soo, Lee, Eaum Seok, Moon, Hee Seok, Kim, Seok Hyun, Sung, Jae Kyu, Lee, Byung Seok, Jeong, Hyun Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9121514/
https://www.ncbi.nlm.nih.gov/pubmed/35603092
http://dx.doi.org/10.1177/11795549221097941
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author Yeo, Min Kyung
Kang, Sun Hyung
Jeong, Ku Bean
Lee, Hyun Seok
Jeon, Hong Jae
Eun, Hyuk Soo
Lee, Eaum Seok
Moon, Hee Seok
Kim, Seok Hyun
Sung, Jae Kyu
Lee, Byung Seok
Jeong, Hyun Yong
author_facet Yeo, Min Kyung
Kang, Sun Hyung
Jeong, Ku Bean
Lee, Hyun Seok
Jeon, Hong Jae
Eun, Hyuk Soo
Lee, Eaum Seok
Moon, Hee Seok
Kim, Seok Hyun
Sung, Jae Kyu
Lee, Byung Seok
Jeong, Hyun Yong
author_sort Yeo, Min Kyung
collection PubMed
description INTRODUCTION: Although signet ring cell carcinoma (SRC) is a subtype of poorly cohesive carcinoma (PC), the differences in the biological behavior between the 2 morphologically similar carcinomas have not been fully studied. Therefore, we performed transcriptome analysis to evaluate the differences of genetic expressions between SRC and PC. METHODS: The study group consisted of patients with SRC or PC pathology from patients with early gastric cancer (EGC) whose depth of invasion was localized in the mucosal layer. A total of 18 patients were enrolled. The patients were divided into 3 groups based on their histologic type and lymph node (LN) status. Group 1 consisted of patients with PC and positive LN metastasis, Group 2 consisted of patients with PC without LN metastasis, and Group 3 consisted of patients with SRC without LN metastasis. Transcriptome analysis was performed using the nCounter PanCancer Progression Panel Kit. RESULTS: The expression of 77 genes in Group 1 was altered compared to that in normal tissues. The expression of 49 and 13 genes in Groups 2 and 3, respectively, was altered when compared to that in normal tissues. Groups 1 and 2 showed similar genetic expressions. However, Group 3 showed numerous differences in gene expression including Roundabout4 (Robo4) compared to the other groups, especially Group 1. CONCLUSION: Our data suggest that gene expression patterns were different between SRC and PC and expression of ROBO4 may play an important role in the prognosis of SRC and PC type of EGC.
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spelling pubmed-91215142022-05-21 Comparison of Gene Expression Profiles of Signet Ring Cell Carcinoma and Poorly Cohesive Carcinoma in Early Gastric Cancer Yeo, Min Kyung Kang, Sun Hyung Jeong, Ku Bean Lee, Hyun Seok Jeon, Hong Jae Eun, Hyuk Soo Lee, Eaum Seok Moon, Hee Seok Kim, Seok Hyun Sung, Jae Kyu Lee, Byung Seok Jeong, Hyun Yong Clin Med Insights Oncol Special Topic: Gastrointestinal Tumor Heterogeneity and New Treatment Strategies INTRODUCTION: Although signet ring cell carcinoma (SRC) is a subtype of poorly cohesive carcinoma (PC), the differences in the biological behavior between the 2 morphologically similar carcinomas have not been fully studied. Therefore, we performed transcriptome analysis to evaluate the differences of genetic expressions between SRC and PC. METHODS: The study group consisted of patients with SRC or PC pathology from patients with early gastric cancer (EGC) whose depth of invasion was localized in the mucosal layer. A total of 18 patients were enrolled. The patients were divided into 3 groups based on their histologic type and lymph node (LN) status. Group 1 consisted of patients with PC and positive LN metastasis, Group 2 consisted of patients with PC without LN metastasis, and Group 3 consisted of patients with SRC without LN metastasis. Transcriptome analysis was performed using the nCounter PanCancer Progression Panel Kit. RESULTS: The expression of 77 genes in Group 1 was altered compared to that in normal tissues. The expression of 49 and 13 genes in Groups 2 and 3, respectively, was altered when compared to that in normal tissues. Groups 1 and 2 showed similar genetic expressions. However, Group 3 showed numerous differences in gene expression including Roundabout4 (Robo4) compared to the other groups, especially Group 1. CONCLUSION: Our data suggest that gene expression patterns were different between SRC and PC and expression of ROBO4 may play an important role in the prognosis of SRC and PC type of EGC. SAGE Publications 2022-05-18 /pmc/articles/PMC9121514/ /pubmed/35603092 http://dx.doi.org/10.1177/11795549221097941 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Special Topic: Gastrointestinal Tumor Heterogeneity and New Treatment Strategies
Yeo, Min Kyung
Kang, Sun Hyung
Jeong, Ku Bean
Lee, Hyun Seok
Jeon, Hong Jae
Eun, Hyuk Soo
Lee, Eaum Seok
Moon, Hee Seok
Kim, Seok Hyun
Sung, Jae Kyu
Lee, Byung Seok
Jeong, Hyun Yong
Comparison of Gene Expression Profiles of Signet Ring Cell Carcinoma and Poorly Cohesive Carcinoma in Early Gastric Cancer
title Comparison of Gene Expression Profiles of Signet Ring Cell Carcinoma and Poorly Cohesive Carcinoma in Early Gastric Cancer
title_full Comparison of Gene Expression Profiles of Signet Ring Cell Carcinoma and Poorly Cohesive Carcinoma in Early Gastric Cancer
title_fullStr Comparison of Gene Expression Profiles of Signet Ring Cell Carcinoma and Poorly Cohesive Carcinoma in Early Gastric Cancer
title_full_unstemmed Comparison of Gene Expression Profiles of Signet Ring Cell Carcinoma and Poorly Cohesive Carcinoma in Early Gastric Cancer
title_short Comparison of Gene Expression Profiles of Signet Ring Cell Carcinoma and Poorly Cohesive Carcinoma in Early Gastric Cancer
title_sort comparison of gene expression profiles of signet ring cell carcinoma and poorly cohesive carcinoma in early gastric cancer
topic Special Topic: Gastrointestinal Tumor Heterogeneity and New Treatment Strategies
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9121514/
https://www.ncbi.nlm.nih.gov/pubmed/35603092
http://dx.doi.org/10.1177/11795549221097941
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