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Intracranial Volume Not Correlated With Severity in Trigonocephaly

OBJECTIVES: Severity of trigonocephaly varies and potentially affects intracranial volume (ICV) and intracranial pressure (ICP). The aim of this study is to measure ICV in trigonocephaly patients and compare it to normative data and correlate ICV with the severity of the skull deformity according to...

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Autores principales: Kronig, Otto D. M., Kronig, Sophia A. J., Van Adrichem, Léon N. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9121522/
https://www.ncbi.nlm.nih.gov/pubmed/34137298
http://dx.doi.org/10.1177/10556656211025185
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author Kronig, Otto D. M.
Kronig, Sophia A. J.
Van Adrichem, Léon N. A.
author_facet Kronig, Otto D. M.
Kronig, Sophia A. J.
Van Adrichem, Léon N. A.
author_sort Kronig, Otto D. M.
collection PubMed
description OBJECTIVES: Severity of trigonocephaly varies and potentially affects intracranial volume (ICV) and intracranial pressure (ICP). The aim of this study is to measure ICV in trigonocephaly patients and compare it to normative data and correlate ICV with the severity of the skull deformity according to UCSQ (Utrecht Cranial Shape Quantifier). DESIGN: Retrospective study. SETTING: Primary craniofacial center. PATIENTS, PARTICIPANTS: Nineteen preoperative patients with nonsyndromic trigonocephaly (age ≤12 months). INTERVENTION: Intracranial volume was measured on preoperative computed tomography (CT) scans by manual segmentation (OsiriX Fondation). Utrecht Cranial Shape Quantifier was used to quantify the severity of the skull deformity. When present, papilledema as sign of elevated ICP was noted. MAIN OUTCOME MEASURES(S): Measured ICV was compared to Lichtenberg normative cranial volume growth curves, and Pearson correlation coefficient was used to correlate UCSQ with the ICV. RESULTS: Mean age at CT scan was 6 months (2-11). Mean measured ICV was 842 mL (579-1124). Thirteen of h19 patients (11/15 boys and 2/4 girls) had an ICV between ±2 SD curves of Lichtenberg, 2 of 19 (1/15 boys and 1/4 girls) had an ICV less than −2 SD and 4 of 19 (3/15 boys and 1/4 girls) had an ICV greater than +2 SD. Mean UCSQ severity of trigonocephaly was 2.40 (−622.65 to 1279.75). Correlation between severity and ICV was negligible (r = −0.11). No papilledema was reported. CONCLUSIONS: Measured ICV was within normal ranges for trigonocephaly patients, in both mild and severe cases. No correlation was found between severity of trigonocephaly and ICV.
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spelling pubmed-91215222022-05-21 Intracranial Volume Not Correlated With Severity in Trigonocephaly Kronig, Otto D. M. Kronig, Sophia A. J. Van Adrichem, Léon N. A. Cleft Palate Craniofac J Original Articles OBJECTIVES: Severity of trigonocephaly varies and potentially affects intracranial volume (ICV) and intracranial pressure (ICP). The aim of this study is to measure ICV in trigonocephaly patients and compare it to normative data and correlate ICV with the severity of the skull deformity according to UCSQ (Utrecht Cranial Shape Quantifier). DESIGN: Retrospective study. SETTING: Primary craniofacial center. PATIENTS, PARTICIPANTS: Nineteen preoperative patients with nonsyndromic trigonocephaly (age ≤12 months). INTERVENTION: Intracranial volume was measured on preoperative computed tomography (CT) scans by manual segmentation (OsiriX Fondation). Utrecht Cranial Shape Quantifier was used to quantify the severity of the skull deformity. When present, papilledema as sign of elevated ICP was noted. MAIN OUTCOME MEASURES(S): Measured ICV was compared to Lichtenberg normative cranial volume growth curves, and Pearson correlation coefficient was used to correlate UCSQ with the ICV. RESULTS: Mean age at CT scan was 6 months (2-11). Mean measured ICV was 842 mL (579-1124). Thirteen of h19 patients (11/15 boys and 2/4 girls) had an ICV between ±2 SD curves of Lichtenberg, 2 of 19 (1/15 boys and 1/4 girls) had an ICV less than −2 SD and 4 of 19 (3/15 boys and 1/4 girls) had an ICV greater than +2 SD. Mean UCSQ severity of trigonocephaly was 2.40 (−622.65 to 1279.75). Correlation between severity and ICV was negligible (r = −0.11). No papilledema was reported. CONCLUSIONS: Measured ICV was within normal ranges for trigonocephaly patients, in both mild and severe cases. No correlation was found between severity of trigonocephaly and ICV. SAGE Publications 2021-06-17 2022-06 /pmc/articles/PMC9121522/ /pubmed/34137298 http://dx.doi.org/10.1177/10556656211025185 Text en © 2021, American Cleft Palate-Craniofacial Association https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Original Articles
Kronig, Otto D. M.
Kronig, Sophia A. J.
Van Adrichem, Léon N. A.
Intracranial Volume Not Correlated With Severity in Trigonocephaly
title Intracranial Volume Not Correlated With Severity in Trigonocephaly
title_full Intracranial Volume Not Correlated With Severity in Trigonocephaly
title_fullStr Intracranial Volume Not Correlated With Severity in Trigonocephaly
title_full_unstemmed Intracranial Volume Not Correlated With Severity in Trigonocephaly
title_short Intracranial Volume Not Correlated With Severity in Trigonocephaly
title_sort intracranial volume not correlated with severity in trigonocephaly
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9121522/
https://www.ncbi.nlm.nih.gov/pubmed/34137298
http://dx.doi.org/10.1177/10556656211025185
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