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Simultaneous detection of metabolite concentration changes, water BOLD signal and pH changes during visual stimulation in the human brain at 9.4T

This study presents a method to directly link metabolite concentration changes and BOLD response in the human brain during visual stimulation by measuring the water and metabolite signals simultaneously. Therefore, the metabolite-cycling (MC) non-water suppressed semiLASER localization technique was...

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Autores principales: Dorst, Johanna, Borbath, Tamas, Landheer, Karl, Avdievich, Nikolai, Henning, Anke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9121534/
https://www.ncbi.nlm.nih.gov/pubmed/35060409
http://dx.doi.org/10.1177/0271678X221075892
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author Dorst, Johanna
Borbath, Tamas
Landheer, Karl
Avdievich, Nikolai
Henning, Anke
author_facet Dorst, Johanna
Borbath, Tamas
Landheer, Karl
Avdievich, Nikolai
Henning, Anke
author_sort Dorst, Johanna
collection PubMed
description This study presents a method to directly link metabolite concentration changes and BOLD response in the human brain during visual stimulation by measuring the water and metabolite signals simultaneously. Therefore, the metabolite-cycling (MC) non-water suppressed semiLASER localization technique was optimized for functional (1)H MRS in the human brain at 9.4 T. Data of 13 volunteers were acquired during a 26:40 min visual stimulation block-design paradigm. Activation-induced BOLD signal was observed in the MC water signal as well as in the NAA-CH(3) and tCr-CH(3) singlets. During stimulation, glutamate concentration increased 2.3 ± 2.0% to a new steady-state, while a continuous increase over the whole stimulation period could be observed in lactate with a mean increase of 35.6 ± 23.1%. These increases of Lac and Glu during brain activation confirm previous findings reported in literature. A positive correlation of the MC water BOLD signal with glutamate and lactate concentration changes was found. In addition, a pH decrease calculated from a change in the ratio of PCr to Cr was observed during brain activation, particularly at the onset of the stimulation.
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spelling pubmed-91215342022-05-21 Simultaneous detection of metabolite concentration changes, water BOLD signal and pH changes during visual stimulation in the human brain at 9.4T Dorst, Johanna Borbath, Tamas Landheer, Karl Avdievich, Nikolai Henning, Anke J Cereb Blood Flow Metab Original Articles This study presents a method to directly link metabolite concentration changes and BOLD response in the human brain during visual stimulation by measuring the water and metabolite signals simultaneously. Therefore, the metabolite-cycling (MC) non-water suppressed semiLASER localization technique was optimized for functional (1)H MRS in the human brain at 9.4 T. Data of 13 volunteers were acquired during a 26:40 min visual stimulation block-design paradigm. Activation-induced BOLD signal was observed in the MC water signal as well as in the NAA-CH(3) and tCr-CH(3) singlets. During stimulation, glutamate concentration increased 2.3 ± 2.0% to a new steady-state, while a continuous increase over the whole stimulation period could be observed in lactate with a mean increase of 35.6 ± 23.1%. These increases of Lac and Glu during brain activation confirm previous findings reported in literature. A positive correlation of the MC water BOLD signal with glutamate and lactate concentration changes was found. In addition, a pH decrease calculated from a change in the ratio of PCr to Cr was observed during brain activation, particularly at the onset of the stimulation. SAGE Publications 2022-01-21 2022-06 /pmc/articles/PMC9121534/ /pubmed/35060409 http://dx.doi.org/10.1177/0271678X221075892 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Original Articles
Dorst, Johanna
Borbath, Tamas
Landheer, Karl
Avdievich, Nikolai
Henning, Anke
Simultaneous detection of metabolite concentration changes, water BOLD signal and pH changes during visual stimulation in the human brain at 9.4T
title Simultaneous detection of metabolite concentration changes, water BOLD signal and pH changes during visual stimulation in the human brain at 9.4T
title_full Simultaneous detection of metabolite concentration changes, water BOLD signal and pH changes during visual stimulation in the human brain at 9.4T
title_fullStr Simultaneous detection of metabolite concentration changes, water BOLD signal and pH changes during visual stimulation in the human brain at 9.4T
title_full_unstemmed Simultaneous detection of metabolite concentration changes, water BOLD signal and pH changes during visual stimulation in the human brain at 9.4T
title_short Simultaneous detection of metabolite concentration changes, water BOLD signal and pH changes during visual stimulation in the human brain at 9.4T
title_sort simultaneous detection of metabolite concentration changes, water bold signal and ph changes during visual stimulation in the human brain at 9.4t
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9121534/
https://www.ncbi.nlm.nih.gov/pubmed/35060409
http://dx.doi.org/10.1177/0271678X221075892
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