Celastrol mitigates inflammation in sepsis by inhibiting the PKM2-dependent Warburg effect

BACKGROUND: Sepsis involves life-threatening organ dysfunction and is caused by a dysregulated host response to infection. No specific therapies against sepsis have been reported. Celastrol (Cel) is a natural anti-inflammatory compound that shows potential against systemic inflammatory diseases. Thi...

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Detalles Bibliográficos
Autores principales: Luo, Piao, Zhang, Qian, Zhong, Tian-Yu, Chen, Jia-Yun, Zhang, Jun-Zhe, Tian, Ya, Zheng, Liu-Hai, Yang, Fan, Dai, Ling-Yun, Zou, Chang, Li, Zhi-Jie, Liu, Jing-Hua, Wang, Ji-Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9121578/
https://www.ncbi.nlm.nih.gov/pubmed/35596191
http://dx.doi.org/10.1186/s40779-022-00381-4

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