Cargando…

Effects of a novel, 3D printed bilateral arytenoid abductor on canine laryngeal airway resistance ex vivo

BACKGROUND: Laryngeal paralysis is a disease process most commonly seen in older, large breed dogs. When both arytenoid cartilages are affected dogs can develop life-threatening respiratory compromise, therefore surgical intervention is recommended. While there are multiple surgical procedures that...

Descripción completa

Detalles Bibliográficos
Autores principales: MacGillivray, Katelyn E., Bellefeuille, Sean D., Hoffmann, Daniel E., St. Germaine, Lindsay L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9121604/
https://www.ncbi.nlm.nih.gov/pubmed/35596179
http://dx.doi.org/10.1186/s12917-022-03263-y
_version_ 1784711187315818496
author MacGillivray, Katelyn E.
Bellefeuille, Sean D.
Hoffmann, Daniel E.
St. Germaine, Lindsay L.
author_facet MacGillivray, Katelyn E.
Bellefeuille, Sean D.
Hoffmann, Daniel E.
St. Germaine, Lindsay L.
author_sort MacGillivray, Katelyn E.
collection PubMed
description BACKGROUND: Laryngeal paralysis is a disease process most commonly seen in older, large breed dogs. When both arytenoid cartilages are affected dogs can develop life-threatening respiratory compromise, therefore surgical intervention is recommended. While there are multiple surgical procedures that have been described to treat laryngeal paralysis, there remains a considerable risk for postoperative complications, most commonly aspiration pneumonia. The objective of this ex vivo experimental study was to evaluate the effects of a novel, 3D printed bilateral arytenoid abductor on laryngeal airway resistance in canine cadaver larynges. Laryngeal airway resistance was calculated for each specimen before (control) and after placement of a 3D printed, bilateral arytenoid abductor. The airway resistance was measured at an airflow of 10 L/min with the epiglottis closed and at airflows ranging from 15 L/min to 60 L/min with the epiglottis open. The effects of the bilateral arytenoid abductor on laryngeal airway resistance were evaluated statistically. RESULTS: With the epiglottis open, median laryngeal airway resistance in all larynges with a bilateral arytenoid abductor were significantly decreased at airflows of 15 L/min (0.0cmH2O/L/sec), 30 L/min (0.2cmH2O/L/sec), and 45 L/min (0.2cmH2O/L/sec) compared to the controls 15 L/min (0.4cmH2O/L/sec; P = 0.04), 30 L/min (0.9cmH2O/L/sec; P = 0.04), and 45 L/min (1.2cmH2O/L/sec; P = 0.04). When the epiglottis was closed, there was no significant difference in laryngeal resistance between the control (18.8cmH(2)O/L/sec) and the abducted larynges (18.1cmH(2)O/L/sec; P = 0.83). CONCLUSIONS: Placement of a bilateral arytenoid abductor reduced laryngeal resistance in canine cadaver larynges compared to the controls when the epiglottis was open. With the epiglottis closed, there was no loss of laryngeal resistance while the device abducted the arytenoid cartilages. The results of this ex vivo study is encouraging for consideration of further evaluation of the bilateral arytenoid abductor to determine an appropriate material and tolerance of this device in vivo.
format Online
Article
Text
id pubmed-9121604
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-91216042022-05-21 Effects of a novel, 3D printed bilateral arytenoid abductor on canine laryngeal airway resistance ex vivo MacGillivray, Katelyn E. Bellefeuille, Sean D. Hoffmann, Daniel E. St. Germaine, Lindsay L. BMC Vet Res Research BACKGROUND: Laryngeal paralysis is a disease process most commonly seen in older, large breed dogs. When both arytenoid cartilages are affected dogs can develop life-threatening respiratory compromise, therefore surgical intervention is recommended. While there are multiple surgical procedures that have been described to treat laryngeal paralysis, there remains a considerable risk for postoperative complications, most commonly aspiration pneumonia. The objective of this ex vivo experimental study was to evaluate the effects of a novel, 3D printed bilateral arytenoid abductor on laryngeal airway resistance in canine cadaver larynges. Laryngeal airway resistance was calculated for each specimen before (control) and after placement of a 3D printed, bilateral arytenoid abductor. The airway resistance was measured at an airflow of 10 L/min with the epiglottis closed and at airflows ranging from 15 L/min to 60 L/min with the epiglottis open. The effects of the bilateral arytenoid abductor on laryngeal airway resistance were evaluated statistically. RESULTS: With the epiglottis open, median laryngeal airway resistance in all larynges with a bilateral arytenoid abductor were significantly decreased at airflows of 15 L/min (0.0cmH2O/L/sec), 30 L/min (0.2cmH2O/L/sec), and 45 L/min (0.2cmH2O/L/sec) compared to the controls 15 L/min (0.4cmH2O/L/sec; P = 0.04), 30 L/min (0.9cmH2O/L/sec; P = 0.04), and 45 L/min (1.2cmH2O/L/sec; P = 0.04). When the epiglottis was closed, there was no significant difference in laryngeal resistance between the control (18.8cmH(2)O/L/sec) and the abducted larynges (18.1cmH(2)O/L/sec; P = 0.83). CONCLUSIONS: Placement of a bilateral arytenoid abductor reduced laryngeal resistance in canine cadaver larynges compared to the controls when the epiglottis was open. With the epiglottis closed, there was no loss of laryngeal resistance while the device abducted the arytenoid cartilages. The results of this ex vivo study is encouraging for consideration of further evaluation of the bilateral arytenoid abductor to determine an appropriate material and tolerance of this device in vivo. BioMed Central 2022-05-20 /pmc/articles/PMC9121604/ /pubmed/35596179 http://dx.doi.org/10.1186/s12917-022-03263-y Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
MacGillivray, Katelyn E.
Bellefeuille, Sean D.
Hoffmann, Daniel E.
St. Germaine, Lindsay L.
Effects of a novel, 3D printed bilateral arytenoid abductor on canine laryngeal airway resistance ex vivo
title Effects of a novel, 3D printed bilateral arytenoid abductor on canine laryngeal airway resistance ex vivo
title_full Effects of a novel, 3D printed bilateral arytenoid abductor on canine laryngeal airway resistance ex vivo
title_fullStr Effects of a novel, 3D printed bilateral arytenoid abductor on canine laryngeal airway resistance ex vivo
title_full_unstemmed Effects of a novel, 3D printed bilateral arytenoid abductor on canine laryngeal airway resistance ex vivo
title_short Effects of a novel, 3D printed bilateral arytenoid abductor on canine laryngeal airway resistance ex vivo
title_sort effects of a novel, 3d printed bilateral arytenoid abductor on canine laryngeal airway resistance ex vivo
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9121604/
https://www.ncbi.nlm.nih.gov/pubmed/35596179
http://dx.doi.org/10.1186/s12917-022-03263-y
work_keys_str_mv AT macgillivraykatelyne effectsofanovel3dprintedbilateralarytenoidabductoroncaninelaryngealairwayresistanceexvivo
AT bellefeuilleseand effectsofanovel3dprintedbilateralarytenoidabductoroncaninelaryngealairwayresistanceexvivo
AT hoffmanndaniele effectsofanovel3dprintedbilateralarytenoidabductoroncaninelaryngealairwayresistanceexvivo
AT stgermainelindsayl effectsofanovel3dprintedbilateralarytenoidabductoroncaninelaryngealairwayresistanceexvivo